Resistance exercise improves learning and memory and modulates hippocampal metabolomic profile in aged rats.

Autor: Serra FT; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil., Cardoso FDS; Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil., Petraconi N; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil., Dos Santos JCC; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil., Araujo BHS; Brazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970, Brazil., Arida RM; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil., Gomes da Silva S; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Centro Universitário FAMINAS (UNIFAMINAS), Muriaé, MG, Brazil; Hospital de Câncer de Muriaé, Fundação Cristiano Varella (FCV), Muriaé, MG, Brazil. Electronic address: sgomesilva@hotmail.com.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2022 Jan 01; Vol. 766, pp. 136322. Date of Electronic Publication: 2021 Nov 02.
DOI: 10.1016/j.neulet.2021.136322
Abstrakt: Physical activity has been considered an important non-medication intervention to preserve mnemonic processes during aging. However, how resistance exercise promotes such benefits remains unclear. A possible hypothesis is that brain-metabolic changes of regions responsible for memory consolidation is affected by muscular training. Therefore, we analyzed the memory, axiety and the metabolomic of aged male Wistar rats (19-20 months old in the 1st day of experiment) submitted to a 12-week resistance exercise protocol (EX, n = 11) or which remained without physical exercise (CTL, n = 13). Barnes maze, elevated plus maze and inhibitory avoidance tests were used to assess the animals' behaviour. The metabolomic profile was identified by nuclear magnetic resonance spectrometry. EX group had better performance in the tests of learning and spatial memory in Barnes maze, and an increase of short and long-term aversive memories formation in inhibitory avoidance. In addition, the exercised animals showed a greater amount of metabolites, such as 4-aminobutyrate, acetate, butyrate, choline, fumarate, glycerol, glycine, histidine, hypoxanthine, isoleucine, leucine, lysine, niacinamide, phenylalanine, succinate, tyrosine, valine and a reduction of ascorbate and aspartate compared to the control animals. These data indicate that the improvement in learning and memory of aged rats submitted to resistance exercise program is associated by changes in the hippocampal metabolomic profile.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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