Hypoxia-inducible factor-1α expression and breast cancer recurrence in a Danish population-based case control study.

Autor: Collin LJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. lindsay.collin@hci.utah.edu.; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. lindsay.collin@hci.utah.edu.; Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Room 4746, Salt Lake City, UT, 84112, USA. lindsay.collin@hci.utah.edu., Maliniak ML; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Cronin-Fenton DP; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark., Ahern TP; Department of Surgery, The Robert Larner, M.D. College of Medicine, The University of Vermont, Burlington, VT, USA., Christensen KB; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark., Ulrichsen SP; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark., Damkier P; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Hamilton-Dutoit S; Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark., Yacoub R; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Christiansen PM; Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark.; The Danish Breast Cancer Group, Aarhus, Denmark., Sørensen HT; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark., Lash TL; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: Breast cancer research : BCR [Breast Cancer Res] 2021 Nov 04; Vol. 23 (1), pp. 103. Date of Electronic Publication: 2021 Nov 04.
DOI: 10.1186/s13058-021-01480-1
Abstrakt: Background: Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that facilitates the adaptation of cancer cells to hypoxic conditions and may be prognostic of breast cancer recurrence. We evaluated the association of HIF-1α expression with breast cancer recurrence, and its association with timing of breast cancer recurrence.
Methods: In this population-based case-control study, we included women diagnosed with stage I-III breast cancer between 1985 and 2001, aged 35-69 years, registered in the Danish Breast Cancer Group. We identified 541 cases of breast cancer recurrence among women with estrogen receptor (ER)-positive disease who were treated with tamoxifen for at least 1 year (ER+ TAM+). We also enrolled 300 breast cancer recurrence cases among women with ER-negative disease, not treated with tamoxifen, who survived at least 1 year (ER-/TAM-). Controls were recurrence-free breast cancer patients at the time of case diagnosis, matched to recurrence cases on ER/TAM status, date of surgery, menopausal status, cancer stage, and county of residence. Expression of HIF-1α was measured by immunohistochemistry on tissue microarrays. We fitted logistic regression models to compute odds ratios (ORs) and 95% confidence intervals (CIs) associating HIF-1α expression with recurrence, and with timing of recurrence.
Results: HIF-1α expression was observed in 23% of cases and 20% of controls in the ER+/TAM+ stratum, and in 47% of cases and 48% of controls in the ER-/TAM- stratum. We observed a near-null association between HIF-1α expression in both ER/TAM groups (ER+/TAM+ OR = 1.21, 95%CI 0.88, 1.67 and ER-/TAM- OR = 0.97, 95%CI 0.68, 1.39). HIF-1α expression was not associated with time to recurrence among women in the ER+/TAM+ stratum, but was associated with early recurrence among women in the ER-/TAM- stratum.
Conclusion: In this study, HIF-1α expression was not associated with breast cancer recurrence overall but may be associated with early recurrence among women diagnosed with ER- breast cancer.
(© 2021. The Author(s).)
Databáze: MEDLINE
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