Amoebic liver abscess in a COVID-19 patient: a case report.

Autor: Maricuto AL; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela., Velásquez VL; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela., Pineda J; 'Dr. José Antonio O'Daly' Anatomopathological Institute, Central University of Venezuela, Caracas, Venezuela., Flora-Noda DM; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela., Rodríguez I; Radiodiagnosis Department, University Hospital of Caracas, Caracas, Venezuela., Rodríguez-Inés CA; Surgery Department, University Hospital of Caracas, Caracas, Venezuela., Noya-González ÓO; 'Dr. Félix Pifano' Tropical Medicine Institute, Central University of Venezuela, Caracas, Venezuela., Contreras R; 'Dr. Félix Pifano' Tropical Medicine Institute, Central University of Venezuela, Caracas, Venezuela., Omaña-Ávila ÓD; 'Luis Razetti' School of Medicine, Central University of Venezuela, Caracas, Venezuela.; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Escalante-Pérez IA; 'Luis Razetti' School of Medicine, Central University of Venezuela, Caracas, Venezuela.; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Camejo-Ávila NA; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Kuffaty-Akkou NA; 'Luis Razetti' School of Medicine, Central University of Venezuela, Caracas, Venezuela.; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela., Carrión-Nessi FS; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela.; 'Dr. Francisco Battistini Casalta' Health Sciences School, University of Oriente - Bolivar Nucleus, Ciudad Bolivar, Venezuela., Carballo M; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela., Landaeta ME; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela., Forero-Peña DA; Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela. vacter.cv@gmail.com.; Biomedical Research and Therapeutic Vaccines Institute, Ciudad Bolivar, Venezuela. vacter.cv@gmail.com.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2021 Nov 04; Vol. 21 (1), pp. 1134. Date of Electronic Publication: 2021 Nov 04.
DOI: 10.1186/s12879-021-06819-9
Abstrakt: Background: Amoebiasis is a parasitic disease caused by Entamoeba histolytica, which affects people living in low- and middle-income countries and has intestinal and extraintestinal manifestations. To date, knowledge on coronavirus disease 2019 (COVID-19) coinfection with enteric parasites is limited, and E. histolytica coinfection has not been previously described. Here we present the case of a patient with COVID-19 who, during hospitalisation, presented a clinical picture consistent with an amoebic liver abscess (ALA).
Case Presentation: A 54-year-old man, admitted as a suspected case of COVID-19, presented to our hospital with dyspnoea, malaise, fever and hypoxaemia. A nasopharyngeal swab was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse-transcription polymerase chain reaction. After 7 days, he developed diarrhoea, choluria and dysentery. An abdominal ultrasound showed a lesion compatible with a liver abscess; stool examination revealed E. histolytica trophozoites, and additional serology for E. histolytica was positive. After 12 days of treatment with metronidazole, ceftazidime and nitazoxanide, the patient reported acute abdominal pain, and an ultrasound examination revealed free liquid in the abdominal cavity. An emergency exploratory laparotomy was performed, finding 3000 mL of a thick fluid described as "anchovy paste". Computed tomography scan revealed a second abscess. He ended up receiving 21 days of antibiotic treatment and was discharged with satisfactory improvement.
Conclusion: Here we present, to the best of our knowledge, the first report of ALA and COVID-19 co-presenting. Based on their pathophysiological similarities, coinfection with SARS-CoV-2 and E. histolytica could change the patient's clinical course; however, larger studies are needed to fully understand the interaction between these pathogens.
(© 2021. The Author(s).)
Databáze: MEDLINE
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