Sympathetic nerve-adipocyte interactions in response to acute stress.

Autor: Santos GSP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Costa AC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Picoli CC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Rocha BGS; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Sulaiman SO; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Radicchi DC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Pinto MCX; Laboratory of Neuropharmacology, Federal University of Goiás, Goiânia, GO, Brazil., Batista ML Jr; Laboratory of Adipose Tissue Biology, University of Mogi das Cruzes, Mogi das Cruzes, SP, Brazil.; Department of Biochemistry, Boston University School of Medicine, Boston, USA., Amorim JH; Center of Biological Sciences and Health, Federal University of Western Bahia, BA, Barreiras, Brazil., Azevedo VAC; Cellular and Molecular Genetics Laboratory, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Resende RR; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Câmara NOS; Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, SP, Brazil., Mintz A; Department of Radiology, Columbia University Medical Center, New York, NY, USA., Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. birbrair@icb.ufmg.br.; Department of Radiology, Columbia University Medical Center, New York, NY, USA. birbrair@icb.ufmg.br.
Jazyk: angličtina
Zdroj: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2022 Feb; Vol. 100 (2), pp. 151-165. Date of Electronic Publication: 2021 Nov 04.
DOI: 10.1007/s00109-021-02157-0
Abstrakt: Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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