Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity.

Autor: González-Ruíz K; Grupo de Investigación Salud y Movimiento. Programa de Fisioterapia. Facultad de Salud, Universidad Santiago de Cali, Cali, Colombia.; Programa de Doctorado en Ciencias Biomédicas y Biológicas, Escuela de Medicina y Ciencias de la Salud - Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia., Correa-Bautista JE; Grupo Rendimiento Físico Militar 'RENFIMIL', Escuela Militar de Cadetes 'General José María Córdova', Bogotá, Colombia., Izquierdo M; Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Pública de Navarra (UPNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., García-Hermoso A; Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Pública de Navarra (UPNA), Pamplona, Spain.; Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Santiago, Chile., Martínez-Vizcaíno V; Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain.; Faculty of Health Sciences, Universidad Autónoma de Chile, Talca, Chile., Lobelo F; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.; Exercise is Medicine Global Research and Collaboration Center, Atlanta, Georgia, USA., González-Jiménez E; Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain., Schmidt-RioValle J; Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain., Correa-Rodríguez M; Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain., Fernández-Irigoyen J; Proteored-Institute of Health Carlos III (ISCIII), Clinical Neuroproteomics Unit, Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Palomino-Echeverría S; Translational Bioinformatics Unit (TransBio), Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Santamaría E; Proteored-Institute of Health Carlos III (ISCIII), Clinical Neuroproteomics Unit, Navarrabiomed, Navarra Health Department, Public University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Ramírez-Vélez R; Navarrabiomed, Hospital Universitario de Navarra (HUN), Navarra Institute for Health Research (IdiSNA), Universidad Pública de Navarra (UPNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Jazyk: angličtina
Zdroj: Pediatric obesity [Pediatr Obes] 2022 Apr; Vol. 17 (4), pp. e12869. Date of Electronic Publication: 2021 Nov 04.
DOI: 10.1111/ijpo.12869
Abstrakt: Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity.
Methods: Adolescents (n = 120), 11-17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components).
Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (-20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (-16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (-2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (-1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05).
Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.
(© 2021 World Obesity Federation.)
Databáze: MEDLINE
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