2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture.

Autor:	Lopez JAV; RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan., Nogawa T; RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan., Yoshida K; RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan., Futamura Y; RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan., Osada H; RIKEN Center for Sustainable Resource Science, Chemical Biology Research Group, Wako, Saitama, Japan.
Jazyk:	angličtina
Zdroj:	Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Dec 22; Vol. 86 (1), pp. 31-36.
DOI:	10.1093/bbb/zbab192
Abstrakt:	2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5'-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 µm and had no effect on the growth of Arabidopsis at 2 µm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound. (© The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu