Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains.

Autor:	Mooney-Leber SM; Department of Psychology, University of Wisconsin-Stevens Point, Stevens Point, WI, United States., Zeid D; Department of Biobehavioral Health, The Pennsylvania State University, State College, PA, United States., Garcia-Trevizo P; Department of Biobehavioral Health, The Pennsylvania State University, State College, PA, United States., Seemiller LR; Department of Biobehavioral Health, The Pennsylvania State University, State College, PA, United States., Bogue MA; The Jackson Laboratory, Bar Harbor, ME, United States., Grubb SC; The Jackson Laboratory, Bar Harbor, ME, United States., Peltz G; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, United States., Gould TJ; Department of Biobehavioral Health, The Pennsylvania State University, State College, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2021 Oct 18; Vol. 12, pp. 737897. Date of Electronic Publication: 2021 Oct 18 (Print Publication: 2021).
DOI:	10.3389/fpsyt.2021.737897
Abstrakt:	Learning is a critical behavioral process that is influenced by many neurobiological systems. We and others have reported that acetylcholinergic signaling plays a vital role in learning capabilities, and it is especially important for contextual fear learning. Since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (AChE), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. We measured conditioned fear behavior and AChE activity in the dorsal hippocampus, ventral hippocampus, and cerebellum. Acetylcholinesterase activity varied among inbred mouse strains in all three brain regions, and there were significant inter-strain differences in contextual and cued fear conditioning. There was an inverse correlation between fear conditioning outcomes and AChE levels in the dorsal hippocampus. In contrast, the ventral hippocampus and cerebellum AChE levels were not correlated with fear conditioning outcomes. These findings strengthen the link between acetylcholine activity in the dorsal hippocampus and learning, and they also support the premise that the dorsal hippocampus and ventral hippocampus are functionally discrete. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Mooney-Leber, Zeid, Garcia-Trevizo, Seemiller, Bogue, Grubb, Peltz and Gould.)
Databáze:	MEDLINE
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