The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network.

Autor: Selenius JS; Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland. jannica.selenius@helsinki.fi.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. jannica.selenius@helsinki.fi., Silveira PP; Department of Psychiatry, Faculty of Medicine, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada.; Ludmer Centre for Neuroinformatic and Mental Health, Douglas Mental Health University Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC, H4H1R3, Canada., Salonen M; Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland.; Public Health Promotion Unit, The National Institute for Health and Welfare, Helsinki, Finland., Kautiainen H; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., von Bonsdorff M; Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland.; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Kajantie E; National Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Oulu, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Lahti J; Department of Psychology and Logopedics, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.; Turku Institute for Advanced Studies, University of Turku, 20014, Turku, Finland., Eriksson JG; Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology and Human Potential Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wasenius NS; Folkhälsan Research Center, Finbyntie 136 Karjaa, 10300, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Nov 03; Vol. 11 (1), pp. 21588. Date of Electronic Publication: 2021 Nov 03.
DOI: 10.1038/s41598-021-00631-w
Abstrakt: To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7-7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = - 3.4, 95% CI - 5.6 to - 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.
(© 2021. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje