Evaluation of cardiovascular biomarkers and histopathological alterations in cattle naturally infected by Babesia bigemina.

Autor: Rasoulzadeh K; Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran., Esmaeilnejad B; Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. Electronic address: b.esmaeilnejad@urmia.ac.ir., Dalir-Naghadeh B; Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran., Asri-Rezaei S; Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran., Tehrani AA; Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2021 Dec; Vol. 161 (Pt A), pp. 105275. Date of Electronic Publication: 2021 Oct 31.
DOI: 10.1016/j.micpath.2021.105275
Abstrakt: Hemolytic anemia and secondary hypoxia are characteristics of naturally occurring Babesia bigemina infection in cattle. The anemic phase comes with cardiovascular insufficiency due to hypoxia-induced system dysfunction; but to date there is no description of cardiac damage in the infected animals. Therefore, this study was undertaken to investigate hematological parameters, biomarkers of cardiac function and D-dimer in 13 cattle infected with B. bigemina which were unresponsive to standard treatment. The animals were necropsied and the cardiac tissue was examined for histopathologic alterations. A significant parasitemia burden-dependent increase in the cardiac biomarkers and D-dimer level were recorded in the infected cattle compared to the control animals. Thrombocytes count was also significantly lower in the infected animals than the control. Both macroscopic and microscopic hemorrhage, mononuclear infiltrates, and myocardial necrosis were the evident histopathologic findings. These findings suggest that B. bigemina infection can potentially induce cardiac dysfunction in cattle. Furthermore, mechanistic studies should be conducted to understand the mechanisms beyond cardiac complications.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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