Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex.

Autor:	Klink PC; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.; Psychiatry Department, Amsterdam UMC, Amsterdam, Netherlands., Chen X; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands., Vanduffel W; Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, Leuven, Belgium.; Massachusetts General Hospital, Martinos Ctr. for Biomedical Imaging, Charlestown, United States.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Harvard Medical School, Boston, United States., Roelfsema PR; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.; Psychiatry Department, Amsterdam UMC, Amsterdam, Netherlands.; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Nov 03; Vol. 10. Date of Electronic Publication: 2021 Nov 03.
DOI:	10.7554/eLife.67304
Abstrakt:	Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans. Competing Interests: PK, XC, WV, PR No competing interests declared (© 2021, Klink et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu