A guide to adhesion GPCR research.

Autor: Liebscher I; Division of Molecular Biochemistry, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Germany., Cevheroğlu O; Stem Cell Institute, Ankara University, Turkey., Hsiao CC; Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands., Maia AF; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal.; IBMC - Instituto Biologia Molecular e Celular, Universidade do Porto, Portugal., Schihada H; C3 Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden., Scholz N; Division of General Biochemistry, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Germany., Soave M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, UK.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, UK., Spiess K; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Trajković K; Biology of Robustness Group, Mediterranean Institute for Life Sciences, Split, Croatia., Kosloff M; Department of Human Biology, Faculty of Natural Sciences, The University of Haifa, Israel., Prömel S; Institute of Cell Biology, Department of Biology, Heinrich Heine University, Düsseldorf, Germany.
Jazyk: angličtina
Zdroj: The FEBS journal [FEBS J] 2022 Dec; Vol. 289 (24), pp. 7610-7630. Date of Electronic Publication: 2021 Nov 17.
DOI: 10.1111/febs.16258
Abstrakt: Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs 'from bench to bedside' in the future.
(© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
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