Predicting cardiovascular risk using a novel risk score in young and middle-age adults with HIV: associations with biomarkers and carotid atherosclerotic plaque.

Autor:	Rodriguez VJ; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Psychology, University of Georgia, Athens, GA, USA., Abbamonte JM; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Parrish MS; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Jones DL; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Weiss S; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Pallikkuth S; Department of Microbiology and Immunology, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Toborek M; Department of Biochemistry and Molecular Biology, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Alcaide ML; Division of Infectious Disease, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Jayaweera D; Division of Infectious Disease, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Pahwa S; Department of Microbiology and Immunology, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Rundek T; Department of Neurology, 12235University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Public Health Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA., Hurwitz BE; Behavioral Medicine Research Center, 5452University of Miami, Miami, FL, USA.; Department of Psychology, 5452University of Miami, Coral Gables, FL, USA.; Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, 5452University of Miami, Miami, FL, USA., Kumar M; Department of Psychiatry and Behavioral Sciences, 12235University of Miami Miller School of Medicine, Miami, FL, USA.
Jazyk:	angličtina
Zdroj:	International journal of STD & AIDS [Int J STD AIDS] 2022 Feb; Vol. 33 (2), pp. 144-155. Date of Electronic Publication: 2021 Nov 02.
DOI:	10.1177/09564624211050335
Abstrakt:	Background: Traditional risk factors associated with cardiovascular disease (CVD) include older age, smoking, poor diet, lack of exercise, obesity, high blood pressure, high cholesterol, and family history. Young-to-middle age adults (YMAA) are less often identified as being at risk of CVD, but traditional risk scores primarily target older adults and do not accurately estimate risk among YMAA. Methods: This study examined biomarkers associated with CVD risk in YMAA in the context of HIV and cocaine use; risk was assessed by two methods: (1) a relative cardiovascular (CV) risk score that includes several factors and (2) carotid atherosclerotic plaque. Associations between CVD risk (CV risk score and carotid atherosclerotic plaque) and proinflammatory cytokines, markers of immune activation, HIV status, and cocaine use were examined. Participants ( N = 506) included people with and without HIV and people who use or do not use cocaine. Results: Participants' mean age was 36 (SD = 9.53); half (51%) were men. Cocaine use and C-reactive protein were associated with greater relative CV risk scores, but no associations between biomarkers and CV risk emerged. Age and CV risk scores were associated with carotid atherosclerotic plaque, but biomarkers were not. HIV was not associated with CV risk scores or carotid atherosclerotic plaque. Conclusions: Among YMAA, CV risk scores may help providers identify lifestyle changes needed among those at risk for CVD before more advanced risk (e.g., atherosclerotic plaque) is identified. Implications are discussed.
Databáze:	MEDLINE
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