The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT.

Autor: Moon EJ; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Petersson K; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.; Radiation Physics, Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden., Olcina MM; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: International journal of radiation biology [Int J Radiat Biol] 2022; Vol. 98 (3), pp. 439-451. Date of Electronic Publication: 2021 Nov 02.
DOI: 10.1080/09553002.2021.1988178
Abstrakt: Purpose: Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field.
Conclusion: Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumor-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumors and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a perfect example of advances in the field that can leverage tumor hypoxia to improve future radiotherapy treatments.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje