Merkel Cell Carcinoma In Situ: No More Serendipity?
| Autor: | Brem CE; Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA., Wolpowitz D; Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA., Chang KH; Signature Healthcare, Raynham, MA., Bhawan J; Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA. |
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| Jazyk: | angličtina |
| Zdroj: | The American Journal of dermatopathology [Am J Dermatopathol] 2022 Apr 01; Vol. 44 (4), pp. 297-301. |
| DOI: | 10.1097/DAD.0000000000002097 |
| Abstrakt: | Abstract: A 50-year-old man, with a history of extensive sun exposure and multiple previous non-melanoma skin cancers, presented with an asymptomatic 8-× 10-millimeter scaly, skin-colored papule on his right shoulder. Subsequent biopsy and excision revealed epidermal hyperplasia containing large atypical basaloid cells with pagetoid spread. Immunoperoxidase staining for cytokeratin-20 demonstrated a focal perinuclear dot-like pattern, and after excluding other in situ entities, a diagnosis of Merkel cell carcinoma In Situ (MCCIS) was rendered. MCCIS is a very rare entity. Although approximately 18% of Merkel cell carcinomas have epidermal involvement, currently only 17 cases of MCCIS have been reported, of which only 7 had no associated neoplasm. Previously, MCCIS was considered a serendipitous or incidental finding, as most cases co-existed with squamous cell carcinoma in situ. This case is unique in that it was not associated with a squamous lesion, and in addition, the pagetoid spread was unusual and has only occasionally been described. As such, MCCIS should be added to list of in situ epidermal lesions with pagetoid spread. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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