Oral bisphosphonates: Adverse effects on the oral mucosa not related to the jaw bones. A scoping review.

Autor: Psimma C; BT-Academy, Center for Special Care in Dentistry Amsterdam, Amsterdam, The Netherlands., Psimma Z; Private Practice, Zoetermeer, The Netherlands., Willems HC; Department Internal Medicine, Section Geriatrics, Amsterdam UMC, Amsterdam, The Netherlands., Klüter WJ; BENECOMO, Flemish-Netherlands Geriatric Oral Research Group, Nijmegen, The Netherlands.; College of Dental Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands., van der Maarel-Wierink CD; BT-Academy, Center for Special Care in Dentistry Amsterdam, Amsterdam, The Netherlands.; BENECOMO, Flemish-Netherlands Geriatric Oral Research Group, Nijmegen, The Netherlands.; College of Dental Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Oral Medicine, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Gerodontology [Gerodontology] 2022 Dec; Vol. 39 (4), pp. 330-338. Date of Electronic Publication: 2021 Nov 02.
DOI: 10.1111/ger.12590
Abstrakt: Background: Oral bisphosphonates are widely used in the treatment of bone resorptive diseases. There is an evidence that oral bisphosphonates can exert adverse effects on the oral mucosa independently of their effects on the jaw bones.
Objective: To systematically map the literature on adverse effects of oral bisphosphonates on the oral mucosa of adults with bone resorptive diseases.
Design: Scoping review of the literature, including different study designs.
Methods: Systematic searches of the PubMed, LILACS, Google Scholar and EMBASE databases were conducted. Two independent reviewers screened titles and abstracts according to predetermined criteria.
Results: The search retrieved 26 unique articles, comprising 22 case reports, one case series and three reviews describing a total of 56 cases of oral adverse events related to oral bisphosphonates. 88% of the reported cases were female suffering from comorbidities other than metabolic bone diseases. The improper use of the oral bisphosphonate was the most suspected cause of the adverse effect on the oral mucosa. Its management mainly involved withdrawal of the medication.
Conclusion: Adverse effects on the oral mucosa can develop from using oral bisphosphonates. Standardised registration of these adverse effects in university clinics and private practises could provide additional information about their occurrence and severity.
(© 2021 The Authors. Gerodontology published by Gerodontology Association and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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