MORPHOLOGICAL JUSTIFICATION OF THE SALIVARY GLAND TISSUE RESECTION BOUNDARIES DURING SURGICAL TREATMENT OF PATIENTS WITH PLEOMORPHIC ADENOMAS.

Autor:	Brodetskyi IS; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Malanchuk VA; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Dyadyk OO; SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE., Kulbashna YА; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Astapenko OO; BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE., Kapustnyk NV; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE., Myroshnychenko MS; KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
Jazyk:	angličtina
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2021; Vol. 74 (9 cz 1), pp. 2182-2186.
Abstrakt:	Objective: The aim is to substantiate morphologically the resection boundaries of the salivary gland tissue in the surgical treatment of patients with pleomorphic adenoma of different histological variants. Patients and Methods: Materials and methods: The study used autopsy, surgical and biopsy material, divided into 2 groups. Group 1 included autopsy material (n=6), represented by tissue fragments of the parotid salivary gland, in which macroscopic and microscopic examination did not reveal any general pathological processes. Group 2 included surgical and biopsy material from 30 patients, represented by pleomorphic adenomas with adjacent tissue of the salivary gland at a distance of 0.5 cm and 1.0 cm. Histological, morphometric and statistical research methods were used. Results: Results: The morphological features of the salivary gland tissue which was adjacent to the pleomorphic adenoma at a distance of 1.0 cm, practically corresponded to thephysiological norm. However, the tissue of the salivary gland, bordering the tumor at a distance of 0.5 cm, was characterized by pronounced changes. These changes were: violation of the ratio of the specific volumes of the parenchyma and stroma; atrophy of the terminal sections and ducts with cystic expansion of some ducts; thickening of the secretion and formation of calculi in the lumen of some ducts; atrophic and alterative changes in the epithelial lining the terminal sections and ducts; sclerosis and lipomatosis, areas with hyalinosis and dystrophic calcification in the stroma; hemodynamic disturbances in the stroma with a decrease in the number of vessels; pronounced focal or diffuse immune infiltration in the stroma in some areas with the lymphoid follicles formation. Conclusion: Conclusion: The comprehensive study has confirmed that removal of the tumor with the adjacent tissue of the salivary gland at a distance of 1.0 cm in patients with pleomorphic adenoma of various histological variants is the most justified from the morphological point of view.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu