| Autor: |
Karau MJ; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA., Schmidt-Malan SM; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA., Cunningham SA; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA., Mandrekar JN; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA., Pritt BS; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA., Keepers TR; Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA., Serio AW; Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA., Chitra S; Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania, USA., Patel R; Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.; Division of Infectious Diseases, Department of Medicine, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA. |
| Abstrakt: |
Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than saline-treated animals. The emergence of rifampin resistance was observed in 3 of 16 animals with rifampin monotherapy and none with rifampin combination therapy. After treatment, the median tibial bacterial loads were 6.04, 0.1, 4.81, and 5.24 log 10 CFU/g for saline-, rifampin-, vancomycin-, and omadacycline-treated animals, respectively. Omadacycline or vancomycin administered with rifampin yielded no detectable MRSA. Omadacycline administered with rifampin deserves evaluation in humans as a potential treatment for osteomyelitis. |
