Procurement-related liver injury for transplantation: an analysis of the risk factors and consequences in an Australian transplant centre.

Autor: Walcott J; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.; Hepato-Pancreato-Biliary & Transplant Surgery Unit, Austin Health, Melbourne, Victoria, Australia., Fink M; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.; Hepato-Pancreato-Biliary & Transplant Surgery Unit, Austin Health, Melbourne, Victoria, Australia.; Victorian Liver Transplant Unit, Austin Health, Melbourne, Victoria, Australia., Ealing I; Royal Prince Alfred Hospital, UGI, Sydney, New South Wales, Australia., Christophi C; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.; Hepato-Pancreato-Biliary & Transplant Surgery Unit, Austin Health, Melbourne, Victoria, Australia.; Victorian Liver Transplant Unit, Austin Health, Melbourne, Victoria, Australia., Muralidharan V; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.; Hepato-Pancreato-Biliary & Transplant Surgery Unit, Austin Health, Melbourne, Victoria, Australia.; Victorian Liver Transplant Unit, Austin Health, Melbourne, Victoria, Australia.
Jazyk: angličtina
Zdroj: ANZ journal of surgery [ANZ J Surg] 2021 Dec; Vol. 91 (12), pp. 2669-2674. Date of Electronic Publication: 2021 Nov 01.
DOI: 10.1111/ans.17285
Abstrakt: Background: Liver transplantation is an established treatment for liver failure, and its success relies on the quality of the donated organ amongst other factors. Studies on procurement-related liver injury (PRLI) are few and some may not apply to modern-day practice. This is the first Australian study examining risk factors and consequences of PRLI.
Method: The Victorian Liver Transplant Unit database was examined for deceased liver donors from 2010 to 2017. Information regarding the donor, retrieval and subsequent transplantation was obtained. PRLI details were sought from the 'organ retrieval report form'. PRLI risk factors and their complications were analysed.
Results: A total of 420 transplants were included, with 45 injuries in 44 livers (10%), and significant injuries were observed in 4%. Variant anatomy was associated with an increased risk of PRLI (11% vs. 2%, p < 0.001). Complication rates were not significantly different between livers with and without PRLI however a reduction in early graft survival was observed.
Conclusion: This study shows that PRLI is common, and that variant anatomy is associated with an increased risk of injury. Appropriate feedback and benchmarking are important to maintain a high quality in donor surgery.
(© 2021 Royal Australasian College of Surgeons.)
Databáze: MEDLINE
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