Weekly SARS-CoV-2 screening of asymptomatic kindergarten to grade 12 students and staff helps inform strategies for safer in-person learning.

Autor:	Doron S; Tufts Medical Center, Boston, MA, USA., Ingalls RR; Boston Medical Center and Boston University School of Medicine, Boston, MA, USA., Beauchamp A; Wellesley Public Schools, Wellesley, MA, USA., Boehm JS; Broad Institute, Cambridge, MA, USA., Boucher HW; Tufts Medical Center, Boston, MA, USA., Chow LH; Wellesley School Committee, Wellesley, MA, USA., Corridan L; Wellesley Public Schools, Wellesley, MA, USA., Goehringer K; COVID-19 Response Advisors, Washington, DC, USA., Golenbock D; University of Massachusetts Medical School, Worcester, MA, USA., Larsen L; Wellesley Education Foundation, Wellesley, MA, USA., Lussier D; Wellesley Public Schools, Wellesley, MA, USA., Testa M; Wellesley Board of Health, Wellesley, MA, USA., Ciaranello A; Medical Practice Evaluation Center and Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Cell reports. Medicine [Cell Rep Med] 2021 Nov 16; Vol. 2 (11), pp. 100452. Date of Electronic Publication: 2021 Oct 27.
DOI:	10.1016/j.xcrm.2021.100452
Abstrakt:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in K-12 schools was rare during in 2020-2021; few studies included Centers for Disease Control and Prevention (CDC)-recommended screening of asymptomatic individuals. We conduct a prospective observational study of SARS-CoV-2 screening in a mid-sized suburban public school district to evaluate the incidence of asymptomatic coronavirus disease 2019 (COVID-19), document frequency of in-school transmission, and characterize barriers and facilitators to asymptomatic screening in schools. Staff and students undergo weekly pooled testing using home-collected saliva samples. Identification of >1 case in a school prompts investigation for in-school transmission and enhancement of safety strategies. With layered mitigation measures, in-school transmission even before student or staff vaccination is rare. Screening identifies a single cluster with in-school staff-to-staff transmission, informing decisions about in-person learning. The proportion of survey respondents self-reporting comfort with in-person learning before versus after implementation of screening increases. Costs exceed $260,000 for assays alone; staff and volunteers spend 135-145 h per week implementing screening. Competing Interests: The authors declare no competing interests. (© 2021 The Authors.)
Databáze:	MEDLINE
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