Comparative study of SARS-CoV-2 antibody titers between male and female COVID-19 patients living in Kurdistan region of Iraq.

Autor: Ishaq SE; Department of Biology, College of Science, Salahaddin University-Erbil, Iraq., Abdulqadir SZ; Department of Biology, College of Science, Salahaddin University-Erbil, Iraq., Khudhur ZO; Department of Medical Analysis, Faculty of Science, Tishk International University, Erbil, Kurdistan Region, Iraq., Omar SA; Ministry of Health, Kurdistan Regional Government, Erbil, Iraq., Qadir MK; Department of Physiotherapy, Erbil Technical Health College, Erbil Polytechnic University, Erbil, Iraq., Awla HK; Department of Biology, College of Science, Salahaddin University-Erbil, Iraq., Rasul MF; Department of Medical Analysis, Faculty of Science, Tishk International University, Erbil, Kurdistan Region, Iraq., Bapir AA; Awamedica Pharmaceutical Company, Erbil, Iraq., Zanichelli A; Department of Biotechnology, University of Parma, Parma, Italy., Mansoor MK; Faculty of Veterinary & Animal Sciences, The Islamia University of Bahawalpur, Pakistan., Kaleem M; Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan., Rizwan MA; Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan., Smail SW; Department of Biology, College of Science, Salahaddin University-Erbil, Iraq.; Department of Biology, College of Science, Cihan University, Erbil, Kurdistan Region, Iraq., Babaei E; Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
Jazyk: angličtina
Zdroj: Gene reports [Gene Rep] 2021 Dec; Vol. 25, pp. 101409. Date of Electronic Publication: 2021 Oct 24.
DOI: 10.1016/j.genrep.2021.101409
Abstrakt: Recently, there is increasing evidence that coronavirus disease 2019 (COVID-19) causes men to experience more serious symptoms and have a higher mortality rate than women, but the association between sex and immune response stays unknown till now, and weather patient's prognosis associated with sex or not is another vague in COVID-19. In this study, the SARS-CoV-2-specific antibody titer test was performed for 727 patients who were a positive RT-PCR result for COVID-19 and we determined the difference in immune response in both genders. Patients were divided into two groups based on their genders, which were 383 males and 344 females. Plasma was collected from the patients after 17 days of diagnosis with COVID-19, and the concentrations of specific antibodies (IgG and IgM) was measured by multiparametric immunoassay system (VIDAS). Results demonstrated that there was no significant difference in both IgM and IgG production in male participants compared to women. Moreover, despite there was a weak significant positive association between age and IgM in male patients, while there was no significant correlation between IgG and age for the same gender. On the other hand, a slight positive correlation between IgM and IgG with age was observed in female participants. Finally, it concluded that there was no sex biases in patients with COVID-19 in Erbil, Iraq. So, these findings are crucial to treat and care male and female's patients infected with COVID-19 at hospitals.
Competing Interests: There are no conflicting interests declared by the authors.
(© 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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