Association of Ethnicity With Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2 Infection: An International Case-Referent Study.

Autor:	Middelburg JG; Department of Medical Science, Middelburg Solutions, Oegstgeest, Netherlands., Crijnen TEM; Paediatric Intensive Care Unit, Ziekenhuis Netwerk Antwerpen Queen Paola Children's Hospital, Antwerp, Belgium., D'Antiga L; Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo, Italy., Verdoni L; Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo, Italy., Chikermane A; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom., Garg P; Division of Pediatric Critical Care Medicine, University of Mississippi Medical Center, Jackson, MS, United States.; Division of Pediatric Infectious Disease, University of Mississippi Medical Center, Jackson, MS, United States.; Division of Pediatric Cardiology, University of Mississippi Medical Center, Jackson, MS, United States., Acharyya BC; Department of Pediatric Gastroenterology, AMRI Hospitals, Kolkata, India.; Department of Pediatrics, AMRI Hospitals, Kolkata, India.; Department of Pediatric Cardiology, AMRI Hospitals, Kolkata, India., Pruccoli G; Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital, University of Turin, Turin, Italy., Schnapp A; Department of Pediatrics, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Rauf A; Department of Pediatrics, Baby Memorial Hospital, Calicut, India., Middelburg RA; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Oct 15; Vol. 9, pp. 707650. Date of Electronic Publication: 2021 Oct 15 (Print Publication: 2021).
DOI:	10.3389/fped.2021.707650
Abstrakt:	Background: It has been suggested that children and infants can develop multisystem inflammatory syndrome in children (MIS-C) in response to a SARS-CoV-2 infection and that Black children are overrepresented among cases. The aim of the current study was to quantify the association between Black, Asian, or other non-White genetic background and COVID-19-related MIS-C in children and infants. Methods: Eight different research groups contributed cases of MIS-C, potentially related to SARS-CoV-2 infection. Several sensitivity analyses were performed, including additional data available from the literature. Analyses were stratified by geographical region. Results: Seventy-three cases from nine distinct geographical regions were included in the primary analyses. In comparison to White children, the relative risk for developing MIS-C after SARS-CoV-2 infection was 15 [95% confidence interval (CI): 7.1 to 32] for Black children, 11 (CI: 2.2 to 57) for Asian, and 1.6 (CI: 0.58 to 4.2) for other ethnic background. Conclusion: Pediatricians should be aware of the fact that the risk of COVID-19-related MIS-C is severely increased in Black children. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Middelburg, Crijnen, D'Antiga, Verdoni, Chikermane, Garg, Acharyya, Pruccoli, Schnapp, Rauf and Middelburg.)
Databáze:	MEDLINE
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