Investigation of Angiogenesis and Wound Healing Potential Mechanisms of Zinc Oxide Nanorods.
| Autor: | Hassan A; Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI) University of Sadat City, Sadat, Egypt., Elebeedy D; College of Biotechnology, Misr University for Science and Technology, Giza, Egypt., Matar ER; Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Fahmy Mohamed Elsayed A; Holding Company for Vaccine and Sera Production (VACSERA), Giza, Egypt., Abd El Maksoud AI; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute (GEBRI) University of Sadat City, Sadat, Egypt.; College of Biotechnology, Misr University for Science and Technology, Giza, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in pharmacology [Front Pharmacol] 2021 Oct 11; Vol. 12, pp. 661217. Date of Electronic Publication: 2021 Oct 11 (Print Publication: 2021). |
| DOI: | 10.3389/fphar.2021.661217 |
| Abstrakt: | The angiogenesis process is an essential issue in tissue engineering. Zinc oxide nanorods are biocompatible metals capable of generating reactive oxygen species (ROS) that respond to induced angiogenesis through various mechanisms; however, released Zn (II) ions suppress the angiogenesis process. In this study, we fabricated green ZnO nanorods using albumin eggshell as a bio-template and investigate its angiogenic potential through chorioallantoic membrane assay and excision wound healing assay. This study demonstrated that angiogenesis and wound healing processes depend on pro-angiogenic factors as VEGF expression due to ZnO nanorods' exiting. Angiogenesis induced via zinc oxide nanorods may develop sophisticated materials to apply in the wound healing field. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Hassan, Elebeedy, Matar, Fahmy Mohamed Elsayed and Abd El Maksoud.) |
| Databáze: | MEDLINE |
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