Anti-NMDA Receptor Encephalitis in a Patient with Tuberous Sclerosis-Related Brain Tumor: A Case Report.

Autor: Ihl T; Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany., Arlt FA; Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany., Machule ML; Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany., Prüss H; Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany., Audebert HJ; Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: Case reports in neurology [Case Rep Neurol] 2021 Sep 30; Vol. 13 (3), pp. 656-663. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
DOI: 10.1159/000518642
Abstrakt: Anti-NMDA receptor (NMDAR) encephalitis (NMDARE) is an important treatable cause of autoimmune psychosis in all age-groups, which is sometimes associated with tumors, especially ovarian teratomas. Tuberous sclerosis complex (TSC) is an autosomal dominant inherited neurocutaneous disease predisposing for development of benign tumors. We present a case of a 35-year-old woman with recurrent episodes of schizophrenia-like symptoms. Accidentally, MRI revealed TSC-related brain tumors. NMDAR antibody titers were strongly positive in serum and cerebrospinal fluid. This is the first case describing an overlap of NMDARE and TSC-related brain tumors. A review of brain tumors and NMDARE is given in the supplementary material. Although a causal link seems interesting from a pathophysiological point of view, we are in favor of a coincidence.
Competing Interests: The authors confirm that this article content has no conflict of interest.
(Copyright © 2021 by S. Karger AG, Basel.)
Databáze: MEDLINE
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