Safety and efficacy of fluvoxamine in COVID-19 ICU patients: An open label, prospective cohort trial with matched controls.

Autor: Calusic M; Department of Anaesthesiology, Resuscitation and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia., Marcec R; School of Medicine, University of Zagreb, Zagreb, Croatia., Luksa L; Department of Anaesthesiology, Resuscitation and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia., Jurkovic I; Department of Anaesthesiology, Resuscitation and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia., Kovac N; Department of Anaesthesiology, Resuscitation and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia., Mihaljevic S; Department of Anaesthesiology, Resuscitation and Intensive Care, University Hospital Centre Zagreb, Zagreb, Croatia.; School of Medicine, University of Zagreb, Zagreb, Croatia., Likic R; School of Medicine, University of Zagreb, Zagreb, Croatia.; Department of Internal Medicine, Unit of Clinical Pharmacology, University Hospital Centre Zagreb, Zagreb, Croatia.
Jazyk: angličtina
Zdroj: British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 May; Vol. 88 (5), pp. 2065-2073. Date of Electronic Publication: 2021 Dec 01.
DOI: 10.1111/bcp.15126
Abstrakt: Aims: Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in three trials. The aim of this study was to evaluate the safety and efficacy of fluvoxamine in COVID-19 patients if administered later in the course of the disease.
Methods: The study was designed as an open-label, prospective cohort trial with matched controls. In April and May 2021, 51 ICU COVID-19 patients hospitalised in the University Hospital Dubrava and University Hospital Centre Zagreb, Croatia, were treated with fluvoxamine 100 mg three times daily for 15 days in addition to standard therapy and they were prospectively matched for age, gender, vaccination against COVID-19, disease severity and comorbidities with 51 ICU controls.
Results: No statistically significant differences between groups were observed regarding the number of days on ventilator support, duration of ICU or total hospital stay. However, overall mortality was lower in the fluvoxamine group, 58.8% (n = 30/51), than in the control group, 76.5% (n = 39/51), HR 0.58, 95% CI (0.36-0.94, P = .027).
Conclusion: Fluvoxamine treatment in addition to the standard therapy in hospitalised ICU COVID-19 patients could have a positive impact on patient survival. Further studies on the effects of fluvoxamine in COVID-19 patients are urgently required.
(© 2021 British Pharmacological Society.)
Databáze: MEDLINE
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