Pyridinium Alkynylanthracenes as Sensitizers for Photodynamic Therapy.

Autor: Fudickar W; Department of Chemistry, University of Potsdam, Potsdam, Germany., Roder P; Department of Chemistry, University of Potsdam, Potsdam, Germany., Listek M; Department of Biology, University of Potsdam, Potsdam, Germany., Hanack K; Department of Biology, University of Potsdam, Potsdam, Germany., Linker T; Department of Chemistry, University of Potsdam, Potsdam, Germany.
Jazyk: angličtina
Zdroj: Photochemistry and photobiology [Photochem Photobiol] 2022 Jan; Vol. 98 (1), pp. 193-201. Date of Electronic Publication: 2021 Nov 15.
DOI: 10.1111/php.13554
Abstrakt: Photodynamic therapy (PDT) is a mild but effective method to treat certain types of cancer upon irradiation with visible light. Here, three isomeric methylpyridinium alkynylanthracenes 1o─p were evaluated as sensitizers for PDT. Upon irradiation with blue or green light, all three compounds show the ability to initiate strand breaks of plasmid DNA. The mayor species responsible for cleavage is singlet oxygen ( 1 O 2 ) as confirmed by scavenging reagents. Only isomers 1m and 1p can be incorporated into HeLa cells, whereas isomer 1o cannot permeate through the membrane. While isomer 1m targets the cell nucleus, isomer 1p assembles in the cellular cytoplasm and impacts the cellular integrity. This is in accordance with a moderate toxicity of 1p in the dark, whereas 1m exhibits no dark toxicity. Both isomers are suitable as PDT reagents, with a CC 50 of 3 μm and 75 nm, for 1p and 1m, respectively. Thus, derivative 1m, which can be easily synthesized, becomes an interesting candidate for cancer therapy.
(© 2021 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology.)
Databáze: MEDLINE
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