Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex.

Autor:	Gordon EM; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Laumann TO; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Marek S; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Newbold DJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Hampton JM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Seider NA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Montez DF; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Nielsen AM; Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL 60611, USA., Van AN; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA., Zheng A; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Miller R; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Siegel JS; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Kay BP; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Snyder AZ; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Greene DJ; Department of Cognitive Science, University of California San Diego, La Jolla, CA 92093, USA., Schlaggar BL; Kennedy Krieger Institute, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Petersen SE; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychological & Brain Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Nelson SM; Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN 55454, USA., Dosenbach NUF; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Kennedy Krieger Institute, Baltimore, MD 21205, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 Jun 16; Vol. 32 (13), pp. 2868-2884.
DOI:	10.1093/cercor/bhab387
Abstrakt:	The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited in part by the practice of averaging neuroimaging data across individuals. Here we utilized highly sampled resting-state functional connectivity MRI for individual-specific precision functional mapping (PFM) of corticostriatal connections. We identified ten individual-specific subnetworks linking cortex-predominately frontal cortex-to striatum, most of which converged with nonhuman primate tract-tracing work. These included separable connections between nucleus accumbens core/shell and orbitofrontal/medial frontal gyrus; between anterior striatum and dorsomedial prefrontal cortex; between dorsal caudate and lateral prefrontal cortex; and between middle/posterior putamen and supplementary motor/primary motor cortex. Two subnetworks that did not converge with nonhuman primates were connected to cortical regions associated with human language function. Thus, precision subnetworks identify detailed, individual-specific, neurobiologically plausible corticostriatal connectivity that includes human-specific language networks. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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