Acute autonomic effects of rose oxide on cardiovascular parameters of Wistar and spontaneously hypertensive rats.

Autor: Dos Santos RB; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil., de C Oliveira LV; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil., Sena EP; Research Center for Medicinal Plants, Federal University of Piauí, Teresina, PI, Brazil., de Sousa DP; Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil., Maia Filho ALM; Nucleus of Research in Biotechnology, State University of Piauí, Teresina, PI, Brazil., Soriano RN; Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil., da S Lopes L; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil., Branco LGS; Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., de Oliveira AP; Research Center for Medicinal Plants, Federal University of Piauí, Teresina, PI, Brazil., Salgado HC; Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Sabino JPJ; Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil. Electronic address: jacobsabino@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Dec 15; Vol. 287, pp. 120107. Date of Electronic Publication: 2021 Oct 27.
DOI: 10.1016/j.lfs.2021.120107
Abstrakt: Aims: Anti-inflammatory molecules, such as rose oxide (RO), are likely to exert therapeutic effects in systemic arterial hypertension (SAH), a disease associated with abnormal immune responses. We aimed to investigate acute autonomic effects of RO on hemodynamic parameters of Wistar and spontaneously hypertensive rats (SHR).
Methods: Rats were anesthetized and femoral artery and veins were cannulated. Next day, blood pressure (BP) and heart rate (HR) were recorded. Acute effects of RO (1.25, 2.5, or 5.0 mg/kg; iv) on BP, HR, and variability of systolic arterial pressure (SAP) and pulse interval (PI) were assessed. The effects of RO were also investigated in SHR, which received atropine (2 mg/kg), propranolol (4 mg/kg), or hexamethonium (20 mg/kg) 15 min before receiving RO. Vasorelaxant effects of RO (10-10 to 10-4 M) on aortic rings of rats were also assessed.
Key Findings: In Wistar rats, none of the RO doses evoked significant changes in BP, HR, and variability of SAP and PI. On the other hand, in SHR, RO elicited reduction in mean arterial pressure (MAP), and prevented the increase in the low frequency power (LF) of the SAP spectra. Pretreatment with atropine or propranolol did not alter hypotension, but attenuated RO-induced bradycardia. Hexamethonium prevented RO-induced hypotension and bradycardia. RO exerted vasorelaxant effects on aortic rings with (Wistar and SHR) or without functional endothelium (SHR only).
Significance: Rose oxide, a monoterpene with anti-inflammatory properties, acts as an antihypertensive molecule due to its ability to acutely promote hypotension and bradycardia in spontaneously hypertensive rats.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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