Coffea arabica extracts and their chemical constituents in a murine model of gouty arthritis: How they modulate pain and inflammation.

Autor: Matosinhos RC; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Bezerra JP; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Barros CH; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Fernandes Pereira Ferreira Bernardes AC; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Coelho GB; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Carolina de Paula Michel Araújo M; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Dian de Oliveira Aguiar Soares R; Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil., Sachs D; Instituto de Física e Química, Universidade Federal de Itajubá, Itajubá, Minas Gerais, 37500-903, Brazil., Saúde-Guimarães DA; Laboratório de Plantas Medicinais LAPLAMED, Programa de Pós-Graduação em Ciências Farmacêuticas CiPharma, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, 35400-000, Brazil. Electronic address: saude@ufop.edu.br.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2022 Feb 10; Vol. 284, pp. 114778. Date of Electronic Publication: 2021 Oct 28.
DOI: 10.1016/j.jep.2021.114778
Abstrakt: Ethnopharmacological Relevance: Coffea arabica is commonly known for its cardiotonic and neurotonic activities, but in some places' folk medicine, like in Arabia and Africa, C. arabica is used to treat headache, migraine, the flu, anemia, oedema, asthenia, asthma, inflammation and wounds.
Aims of the Study: The aims were to evaluate if the aqueous extracts of Coffea arabica, prepared from beans with different degrees of roasting, and their main chemical constituents could exert an in vivo anti-gouty effect.
Materials and Methods: Coffea extracts were obtained from the beans of not roasted, light, medium and dark roasted coffee and from decaffeinated and traditional coffees and were prepared with water at 25°C and at 98°C. C57BL/6 mice were induced to gout by an injection of monosodium urate crystals and treated with coffee extracts at doses of 25, 75 and 225 mg/kg and their chemical constituents at a dose of 10 mg/kg. The antinociceptive and anti-inflammatory effects were evaluated.
Results: Treatments with Coffea extracts prepared with water at 98°C were more effective to exert antinociceptive and anti-inflammatory activities than the ones prepared with water at 25°C. Caffeic and chlorogenic acids reduced hypernociception in animals when compared with negative control group (7.79 and 5.69 vs 18.53; P < 0.05 and P < 0.001, respectively), inhibited neutrophil migration (1.59 × 104 and 0.38 × 104 vs 9.47 × 104; P < 0.0001 both) and decreased pro-inflammatory cytokines concentration (IL-1β, IL-6 and TNF-α).
Conclusions: We have demonstrated that our treatments attenuated gout, and this effect could be attributed to a reducement in hypernociception, neutrophil migration and cytokines concentration. These results suggest coffee as a potential candidate for studies in acute gout therapy.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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