Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions.

Autor: Singh M; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi-110067 India., Thakur M; Department of Microbiology, Central University of Haryana, Mahendergarh, Haryana-123031 India., Mishra M; Division of Cell Biology and Immunology, Council of Scientific and Industrial Research- Institute of Microbial Technology, Chandigarh-160036 India., Yadav M; Division of Cell Biology and Immunology, Council of Scientific and Industrial Research- Institute of Microbial Technology, Chandigarh-160036 India., Vibhuti R; Department of Microbiology, Central University of Haryana, Mahendergarh, Haryana-123031 India., Menon AM; Genome and computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001 India., Nagda G; Department of Zoology, Mohanlal Sukhadia University, Udaipur, Rajasthan-313001 India., Dwivedi VP; International Centre for Genetic Engineering and Biotechnology, ICGEB Campus, Aruna Asaf Ali Marg, New Delhi-110067 India., Dakal TC; Genome and computational Biology Lab, Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001 India., Yadav V; Department of Microbiology, Central University of Haryana, Mahendergarh, Haryana-123031 India.
Jazyk: angličtina
Zdroj: Immunology letters [Immunol Lett] 2021 Dec; Vol. 240, pp. 123-136. Date of Electronic Publication: 2021 Oct 29.
DOI: 10.1016/j.imlet.2021.10.007
Abstrakt: Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecules which is responsible for several immune functions like T cell activation, extravasation, inflammation, etc. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators like cellular stress, proinflammatory cytokines, viral infection. These stimuli modulate the expression of ICAM-1 primarily through regulating the ICAM-1 gene transcription. On account of the presence of various binding sites for NF-κB, AP-1, SP-1, and many other transcription factors, the architecture of the ICAM-1 promoter become complex. Transcription factors in union with other transcription factors, coactivators, and suppressors promote their assembly in a stereospecific manner on ICAM-1 promoter which mediates ICAM-1 regulation in response to different stimuli. Along with transcriptional regulation, epigenetic modifications also play a pivotal role in controlling ICAM-1 expression on different cell types. In this review, we summarize the regulation of ICAM-1 expression both at the transcriptional as well as post-transcriptional level with an emphasis on transcription factors and signaling pathways involved.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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