Causes of the Failure of Biological Therapy at a Tertiary Center: A Cross-Sectional Retrospective Study.

Autor:	Fatani AZ; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Bugshan NA; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., AlSayyad HM; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Shafei MA; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Hariri NM; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Alrashid LT; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Lasker AY; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Aldauig BA; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Attar SM; Department of Internal Medicine, King Abdulaziz University, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Sep 24; Vol. 13 (9), pp. e18253. Date of Electronic Publication: 2021 Sep 24 (Print Publication: 2021).
DOI:	10.7759/cureus.18253
Abstrakt:	Introduction Rheumatoid arthritis (RA) is one of the most commonly encountered autoimmune diseases. Treatment generally includes disease-modifying anti-rheumatic drugs (DMARDs) and/or biological therapy. However, a significant proportion of the patients do not respond to treatment either as a (primary failure) or lose efficacy over time (secondary failure). Several factors are assumed to influence these conditions. Objectives To estimate the prevalence of failure of biological therapy in patients with RA and its causes. Methods A total of 335 RA patients who were diagnosed at a tertiary center in Jeddah, Saudi Arabia, and had a failure after receiving biological therapy were included in this study. Several variables were considered; patient's socio-demographic data, comorbid conditions, types of biological therapy, the duration of using biological therapy in months, number of biological therapies, allergic reactions, disease activity, and treatment duration. Results Overall the prevalence of failure to biological therapy was 58%; 77% primary failure and 23% secondary failure. Patients with negative rheumatoid factor (RF) (p=0.006), using low-dose steroids, and with a longer disease duration had a significant failure of biological therapy (p=0.023). Conclusion A high percentage of RA patients had a failure of biological therapy. A multicentric trial is recommended to look for additional factors. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Fatani et al.)
Databáze:	MEDLINE
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