Predictors and outcomes of acute respiratory failure in hospitalised patients with acute pancreatitis.

Autor:	Gajendran M; Internal Medicine, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Prakash B; Pulmonary and Critical Care Medicine, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Perisetti A; Gastroenterology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Umapathy C; Gastroenterology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Gupta V; UCSD, La Jolla, California, USA., Collins L; Internal Medicine, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Rawla P; Internal Medicine, Memorial Hospital of Martinsville and Henry County, Martinsville, Virginia, USA., Loganathan P; Internal Medicine, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Dwivedi A; Department of Biostatistics, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Dodoo C; Department of Biostatistics, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Unegbu F; University of Arizona, Arizona Health Sciences Center, Tucson, Arizona, USA., Schuller D; Pulmonary and Critical Care Medicine, Texas Tech University Health Sciences Center El Paso, Paul L Foster School of Medicine, El Paso, Texas, USA., Goyal H; Internal Medicine, Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA.; Internal Medicine, Mercer University School of Medicine, Macon, Georgia, USA., Saligram S; Gastroenterology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Jazyk:	angličtina
Zdroj:	Frontline gastroenterology [Frontline Gastroenterol] 2020 Jul 28; Vol. 12 (6), pp. 478-486. Date of Electronic Publication: 2020 Jul 28 (Print Publication: 2021).
DOI:	10.1136/flgastro-2020-101496
Abstrakt:	Background and Aim: Acute pancreatitis (AP) is associated with organ failures and systemic complications, most commonly acute respiratory failure (ARF) and acute kidney injury. So far, no studies have analysed the predictors and hospitalisation outcomes, of patients with AP who developed ARF. The aim of this study was to measure the prevalence of ARF in AP and to determine the clinical predictors for ARF and mortality in AP. Methods: This is a retrospective cohort study using the Nationwide Inpatient Sample database from the year 2005-2014. The study population consisted of all hospitalisations with a primary or secondary discharge diagnosis of AP, which is further stratified based on the presence of ARF. The outcome measures include in-hospital mortality, hospital length of stay and hospitalisation cost. Results: In our study, about 5.4% of patients with AP had a codiagnosis of ARF, with a mortality rate of 26.5%. The significant predictors for ARF include sepsis, pleural effusion, pneumonia and cardiogenic shock. Key variables that were associated with a higher risk of mortality include mechanical ventilation, age more than 65 years, sepsis and cancer (excluding pancreatic cancer). The presence of ARF increased hospital stay by 8.3 days and hospitalisation charges by US$103 460. Conclusion: In this study, we demonstrate that ARF is a significant risk factor for increased hospital mortality, greater length of stay and higher hospitalisation charges in patients with AP. This underlines significantly higher resource utilisation in patients with a dual diagnosis of AP-ARF. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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