Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy.

Autor:	Lauriero G; Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.; INSERM U1149, Paris, France.; CNRS ERL8252, Paris, France.; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy., Abbad L; Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.; INSERM U1149, Paris, France.; CNRS ERL8252, Paris, France., Vacca M; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy., Celano G; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy., Chemouny JM; Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.; INSERM U1149, Paris, France.; CNRS ERL8252, Paris, France., Calasso M; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy., Berthelot L; Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France., Gesualdo L; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy., De Angelis M; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy., Monteiro RC; Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France.; INSERM U1149, Paris, France.; CNRS ERL8252, Paris, France.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Oct 12; Vol. 12, pp. 694787. Date of Electronic Publication: 2021 Oct 12 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.694787
Abstrakt:	Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Several observations suggest that gut microbiota could be implicated in IgAN pathophysiology. Aiming at exploring whether microbiota modulation is able to influence disease outcome, we performed fecal microbiota transplantation (FMT) from healthy controls (HC-sbjs), non-progressor (NP-pts) and progressor (P-pts) IgAN patients to antibiotic-treated humanized IgAN mice (α1KI-CD89Tg), by oral gavage. FMT was able to modulate renal phenotype and inflammation. On one hand, the microbiota from P-pts was able to induce an increase of serum BAFF and galactose deficient-IgA1 levels and a decrease of CD89 cell surface expression on blood CD11b + cells which was associated with soluble CD89 and IgA1 mesangial deposits. On the other hand, the microbiota from HC-sbjs was able to induce a reduction of albuminuria immediately after gavage, an increased cell surface expression of CD89 on blood CD11b + cells and a decreased expression of KC chemokine in kidney. Higher serum BAFF levels were found in mice subjected to FMT from IgAN patients. The main bacterial phyla composition and volatile organic compounds profile significantly differed in mouse gut microbiota. Microbiota modulation by FMT influences IgAN phenotype opening new avenues for therapeutic approaches in IgAN. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Lauriero, Abbad, Vacca, Celano, Chemouny, Calasso, Berthelot, Gesualdo, De Angelis and Monteiro.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu