Age-related immune alterations and cerebrovascular inflammation.

Autor: Finger CE; Department of Neurology, McGovern Medical School, UTHealth Science Center at Houston, Houston, TX, USA., Moreno-Gonzalez I; Department of Neurology, McGovern Medical School, UTHealth Science Center at Houston, Houston, TX, USA.; Department of Cell Biology, Genetics and Physiology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Faculty of Sciences, Malaga University, Malaga, Spain.; Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Malaga, Spain., Gutierrez A; Department of Cell Biology, Genetics and Physiology, Instituto de Investigacion Biomedica de Malaga-IBIMA, Faculty of Sciences, Malaga University, Malaga, Spain.; Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Malaga, Spain., Moruno-Manchon JF; Department of Neurology, McGovern Medical School, UTHealth Science Center at Houston, Houston, TX, USA., McCullough LD; Department of Neurology, McGovern Medical School, UTHealth Science Center at Houston, Houston, TX, USA. louise.d.mccullough@uth.tmc.edu.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2022 Feb; Vol. 27 (2), pp. 803-818. Date of Electronic Publication: 2021 Oct 28.
DOI: 10.1038/s41380-021-01361-1
Abstrakt: Aging is associated with chronic systemic inflammation, which contributes to the development of many age-related diseases, including vascular disease. The world's population is aging, leading to an increasing prevalence of both stroke and vascular dementia. The inflammatory response to ischemic stroke is critical to both stroke pathophysiology and recovery. Age is a predictor of poor outcomes after stroke. The immune response to stroke is altered in aged individuals, which contributes to the disparate outcomes between young and aged patients. In this review, we describe the current knowledge of the effects of aging on the immune system and the cerebral vasculature and how these changes alter the immune response to stroke and vascular dementia in animal and human studies. Potential implications of these age-related immune alterations on chronic inflammation in vascular disease outcome are highlighted.
(© 2021. The Author(s).)
Databáze: MEDLINE
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