The Effect of Hearing Aid Use on the Association Between Hearing Loss and Brain Structure in Older Adults.

Autor:	de Boer TG; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Rigters SC; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Croll PH; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Niessen WJ; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., van der Schroeff MP; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Goedegebure A; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Ear and hearing [Ear Hear] 2022 May/Jun; Vol. 43 (3), pp. 933-940.
DOI:	10.1097/AUD.0000000000001148
Abstrakt:	Objectives: Recent studies have shown an association between poorer hearing thresholds and smaller brain tissue volumes in older adults. Several underlying causal mechanisms have been opted, with a sensory deprivation hypothesis as one of the most prominent. If hearing deprivation would lead to less brain volume, hearing aids could be hypothesized to moderate this pathway by restoration of hearing. This study aims to investigate whether such a moderating effect of hearing aids exists. Design: The authors conducted a cross-sectional study involving aging participants of the population-based Rotterdam Study. Hearing aid use was assessed by interview and hearing loss was quantified using pure-tone audiometry. Total brain volume, gray matter and white matter volume and white matter integrity [fractional anisotropy (FA) and mean diffusivity] were measured using magnetic resonance imaging. Only participants with a pure tone average at 1, 2, and 4 kHz (PTA1,2,4) of ≥35 dB HL were included. Associations of hearing loss with brain volume and global measures of white matter integrity were analyzed using linear regression, with hearing aid use and interaction between hearing aid use and PTA1,2,4 included as independent variables. Models were adjusted for age, sex, time between audiometry and magnetic resonance imaging, level of education, and cardiovascular risk factors. Results: Out of 459 included participants with mean age (range) 70.4 (52 to 92) 41% were female. Distributions of age and sex among hearing aid users (n = 172) did not significantly differ from those without hearing aids. PTA1,2,4 was associated with lower FA, but not with a difference in total brain volume, gray matter volume, white matter volume, or mean diffusivity. Interaction between hearing aid use and PTA1,2,4 was not associated with FA or any of the other outcome measures. Additional analysis revealed that interaction between hearing aid use and age was associated with lower FA. Conclusions: We found no evidence for a moderating effect of hearing aids on the relationship between hearing loss and brain structure in a population of older adults. However, use of hearing aids did appear as an effect modifier in the association between age and white matter integrity. Future longitudinal research is needed to clarify these results. Competing Interests: S. C. R. reports funding by Heinsius Houbolt Foundation. P. H. C. reports funding by Cochlear Ltd. W. J. N. is founder, scientific lead, and shareholder of Quantib BV. For the remaining authors, no potential conflicts of interest were declared. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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