Predıctıve value of pregnancy of follıcular fluıd fetuın-A and -B levels ın infertıle women after intra-cytoplasmic sperm injection.

Autor: Yurtcu N; Department of Obstetrics and Gynecology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey., Oral S; Department of Obstetrics and Gynecology, Faculty of Medicine, Halic University, Istanbul, Turkey., Celik S; Department of Obstetrics and Gynecology, Balikesir State Hospital, Balikesir, Turkey., Calıskan ST; Department of Urology, Samsun Gazi State Hospital, Samsun, Turkey., Alagoz M; In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Medical Park Hospital, Samsun, Turkey., Dahan MH; McGill University Reproductive Center, Montréal, Quebec, Canada.
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2022 Jan; Vol. 48 (1), pp. 178-187. Date of Electronic Publication: 2021 Oct 28.
DOI: 10.1111/jog.15070
Abstrakt: Aim: We aimed to investigate the value of follicular fluid fetuins-A and -B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve.
Methods: The follicular fluid of 96 infertile women who underwent intra-cytoplasmic sperm injection (ICSI) procedure was analyzed. Fetuins-A and -B levels were examined and compared in those who could achieve pregnancy and those who could not. Receiver operating characteristic curve analyzes were used to determine cut-off and statistically significant associations for fetuins-A and -B.
Results: Follicular fluid fetuin-A levels were higher in cases with weak ovarian reserve (OR) (p < 0.05) and higher in patients who did not achieve clinical pregnancy (p < 0.05). Conversely, the follicular fluid fetuin-B levels were lower in cases with poor OR (p < 0.05) and were lower in patients who did not achieve a clinical pregnancy (p < 0.05). A follicular fluid fetuin-A concentration ≤ 19.12 ng/mL had a sensitivity and specificity of 94.74% and 93.1%, respectively, at predicting clinical pregnancy. While the follicular fluid fetuin-B concentration >24.7 ng/mL had sensitivity and specificity of 71.1% and 51.7%, respectively, for clinical pregnancy prediction.
Conclusion: Overall, high levels of follicular fluid fetuin-A may be independently associated with unsuccessful IVF irrespective of OR grouping. A low level of follicular fetuin-B was also associated with failed IVF. The sensitivity and specificity were found to be higher for fetuin-A in predicting clinical pregnancy. Therefore, the follicular fluid fetuin-A may be more predictive for successful IVF and clinical pregnancy outcomes than follicular fluid fetuin-B.
(© 2021 Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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