Epigenetic Repair of Terrifying Lucid Dreams by Enhanced Brain Reward Functional Connectivity and Induction of Dopaminergic Homeostatic Signaling.

Autor:	Blum K; Western University Health Sciences, Pomona, CA., USA.; Department Psychiatry, Wright University, Boonshoff School of Medicine, Dayton, OH., USA.; Division of Neuroscience & Addiction Research Therapy, Pathway Healthcare, Birmingham, AL., USA.; Division of Nutrigenomics, Geneus Genomic Testing Center, Geneus Health, LLC., San Antonio, TX., USA.; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary., McLaughlin T; Center for Psychiatric Medicine, Laurence, MA., USA., Modestino EJ; Department of Psychology, Curry College, Milton. MA., USA., Baron D; Department Psychiatry, Wright University, Boonshoff School of Medicine, Dayton, OH., USA., Bowirrat A; Department of Neuroscience and Genetics, Interdisciplinary Center Herzliya, Israel., Brewer R; Division of Nutrigenomics, Geneus Genomic Testing Center, Geneus Health, LLC., San Antonio, TX., USA., Steinberg B; Department of Psychology, Curry College, Milton. MA., USA., Roy AK; Department of Psychiatry, School of Medicine, University of Tulane, New Orleans, LA., USA., Febo M; Department of Psychiatry, McKnight Brain Institute, University of Florida, School of Medicine, Gainesville, FL.USA., Badgaiyan RD; Department of Psychiatry, Ichan School of Medicine, Mount Sinai Hospital, New York, NY.& Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, San Antonio, TX, Long School of Medicine, University of Texas Medical Center, San Antonio, TX, USA., Gold MS; Department of Psychiatry, Washington University School of Medicine, St. Louis, Mo. USA.
Jazyk:	angličtina
Zdroj:	Current psychopharmacology [Curr Psychopharmacol] 2021 Feb 15; Vol. 10.
DOI:	10.2174/2211556010666210215153513
Abstrakt:	During Lucid Dreams, the dreamer is aware, experiences the dream as if fully awake, and may control the dream content. The dreamer can start, stop, and restart dreaming, depending on the nature and pleasantness of the dream. For patients with Reward Deficiency Syndrome (RDS) behaviors, like Attention Deficit Hyperactivity Disorder (ADHD), Tourette's- Syndrome, and Posttraumatic Stress Disorder (PTSD), the dream content may be pleasant, unpleasant, or terrifying. A sample of psychiatric center patients identified as having RDS reported the effectiveness of a neuronutrient, dopamine agonist, KB200Z, in combating terrifying, lucid dreaming. These reports motivated the study of eight clinical cases with known histories of substance abuse, childhood abuse, and PTSD. The administration of KB200Z, associated with eliminating unpleasant or terrifying lucid dreams in 87.5% of the cases. Subsequently, other published cases have further established the possibility of the long-term elimination of terrifying dreams in PTSD and ADHD patients. Induction of dopamine homeostasis may mitigate the effects of neurogenetic and epigenetic changes in neuroplasticity, identified in the pathogenesis of PTSD and ADHD. The article explores how relief of terrifying lucid dreams may benefit from modulation of dopaminergic signaling activated by the administration of a neuronutrient. Recently, precision formulations of the KB220 neuronutrient guided by Genetic Addiction Risk Score (GARS) test results have been used to repair inheritable deficiencies within the brain reward circuitry. The proposition is that improved dopamine transmodulational signaling may stimulate positive cognitive recall and subsequently attenuate the harmful epigenetic insults from trauma. Competing Interests: CONFLICT OF INTEREST KB is a chairman and CSO of the Geneus Health Board of Directors and CSO. He is the inventor of GARS and the Pro-dopamine regulator (KB220PBM) and credited with the patents issued and pending. Through their company, Igene KB owns stock in Geneus Health RB and KB are members of the GeneUs Health LLC Board KB is also the Chairman of the Board of Directors and Scientific Advisory Board of Geneus Health that includes MGL, EJM, PKT, RDB, and DB. There are no other conflicts to report.]
Databáze:	MEDLINE
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