Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.

Autor:	Bown CW; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Khan OA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biostatistics (O.A.K., D.L.), Vanderbilt University Medical Center, Nashville, TN., Moore EE; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Liu D; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biostatistics (O.A.K., D.L.), Vanderbilt University Medical Center, Nashville, TN., Pechman KR; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Cambronero FE; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Terry JG; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Nair S; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Davis LT; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN., Gifford KA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN., Landman BA; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Radiology and Radiological Sciences (J.G.T., S.N., L.T.D., B.A.L.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Engineering (B.A.L., A.L.J.), Vanderbilt University, Nashville, TN.; Department of Electrical Engineering and Computer Science (B.A.L.), Vanderbilt University, Nashville, TN., Hohman TJ; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute (T.J.H.), Vanderbilt University Medical Center, Nashville, TN., Carr JJ; Division of Cardiovascular Medicine, Department of Medicine (J.J.C.), Vanderbilt University Medical Center, Nashville, TN., Jefferson AL; Vanderbilt Memory & Alzheimer's Center (C.W.B., O.A.K., E.E.M., D.L., K.R.P., F.E.C., L.T.D., K.A.G., B.A.L., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Neurology (K.R.P., L.T.D., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Engineering (B.A.L., A.L.J.), Vanderbilt University, Nashville, TN.
Jazyk:	angličtina
Zdroj:	Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Dec; Vol. 41 (12), pp. 3015-3024. Date of Electronic Publication: 2021 Oct 28.
DOI:	10.1161/ATVBAHA.121.316477
Abstrakt:	Objective: To determine whether baseline aortic stiffness, measured by aortic pulse wave velocity (PWV), relates to longitudinal cerebral gray or white matter changes among older adults. Baseline cardiac magnetic resonance imaging will be used to assess aortic PWV while brain magnetic resonance imaging will be used to assess gray matter and white matter hyperintensity (WMH) volumes at baseline, 18 months, 3 years, 5 years, and 7 years. Approach and Results: Aortic PWV (m/s) was quantified from cardiac magnetic resonance. Multimodal 3T brain magnetic resonance imaging included T 1 -weighted imaging for quantifying gray matter volumes and T 2 -weighted fluid-attenuated inversion recovery imaging for quantifying WMHs. Mixed-effects regression models related baseline aortic PWV to longitudinal gray matter volumes (total, frontal, parietal, temporal, occipital, hippocampal, and inferior lateral ventricle) and WMH volumes (total, frontal, parietal, temporal, and occipital) adjusting for age, sex, race/ethnicity, education, cognitive diagnosis, Framingham stroke risk profile, APOE (apolipoprotein E)-ε4 carrier status, and intracranial volume. Two hundred seventy-eight participants (73±7 years, 58% male, 87% self-identified as non-Hispanic White, 159 with normal cognition, and 119 with mild cognitive impairment) from the Vanderbilt Memory & Aging Project (n=335) were followed on average for 4.9±1.6 years with PWV measurements occurring from September 2012 to November 2014 and longitudinal brain magnetic resonance imaging measurements occurring from September 2012 to June 2021. Higher baseline aortic PWV was related to greater decrease in hippocampal (β=-3.6 [mm 3 /y]/[m/s]; [95% CI, -7.2 to -0.02] P =0.049) and occipital lobe (β=-34.2 [mm 3 /y]/[m/s]; [95% CI, -67.8 to -0.55] P =0.046) gray matter volume over time. Higher baseline aortic PWV was related to greater increase in WMH volume over time in the temporal lobe (β=17.0 [mm 3 /y]/[m/s]; [95% CI, 7.2-26.9] P <0.001). All associations may be driven by outliers. Conclusions: In older adults, higher baseline aortic PWV related to greater decrease in gray matter volume and greater increase in WMHs over time. Because of unmet cerebral metabolic demands and microvascular remodeling, arterial stiffening may preferentially affect certain highly active brain regions like the temporal lobes. These same regions are affected early in the course of Alzheimer disease.
Databáze:	MEDLINE
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