Reduced prefrontal cortex response to own vs. unknown emotional infant faces in mothers with bipolar disorder.

Autor: Bjertrup A; Copenhagen Affective Disorders research Center (CADIC), Psychiatric Centre Copenhagen, Mental Health Services, Denmark; Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Denmark., Macoveanu J; Copenhagen Affective Disorders research Center (CADIC), Psychiatric Centre Copenhagen, Mental Health Services, Denmark., Laurent H; University of Illinois Urbana-Champaign, Champaign, IL, United States., Moszkowicz M; Child- and Adolescent Mental Health Center, Infant Psychiatric Unit, Mental Health Services, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Finnegan MK; University of Illinois Urbana-Champaign, Champaign, IL, United States., Egmose I; Center for Early Intervention and Family Studies, Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Denmark., Fisher PM; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Nielsen RE; Aalborg University Hospital, Psychiatry, Aalborg, Denmark, Department of Clinical Medicine, Aalborg University, Denmark., Pagsberg AK; Child- and Adolescent Mental Health Center, Infant Psychiatric Unit, Mental Health Services, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Kessing LV; Copenhagen Affective Disorders research Center (CADIC), Psychiatric Centre Copenhagen, Mental Health Services, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Væver M; Center for Early Intervention and Family Studies, Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Denmark., Miskowiak K; Copenhagen Affective Disorders research Center (CADIC), Psychiatric Centre Copenhagen, Mental Health Services, Denmark; Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Denmark. Electronic address: kamilla@miskowiak.dk.
Jazyk: angličtina
Zdroj: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2022 Jan; Vol. 54, pp. 7-20. Date of Electronic Publication: 2021 Oct 24.
DOI: 10.1016/j.euroneuro.2021.09.011
Abstrakt: Motherhood involves functional brain adaptations within a broad neural network purported to underlie sensitive caregiving behavior. Bipolar disorder (BD) is associated with aberrant brain response to emotional faces within a similar network, which may influence BD mothers' sensitivity to infant faces. This functional magnetic resonance imaging (fMRI) study aimed to investigate whether mothers with BD display aberrant neural responses to own infant faces compared to healthy mothers. Twenty-six mothers with BD in remission and 35 healthy mothers underwent fMRI during which they viewed happy and distressed still facial photographs of their own and of unknown infants. After the scan, mothers viewed the pictures again on a computer screen and rated the intensity of infants' facial emotions and their own emotional response to infant face images. Mothers with BD displayed lower left dorsolateral prefrontal cortex (dlPFC) response compared to healthy mothers to own vs. unknown infant faces specifically and abnormal positive functional connectivity between the left and right amygdala and prefrontal regions. BD mothers further displayed stronger deactivation of precuneus and occipital regions to all happy vs. distressed infant faces. After the scan, they rated their infants' distress and own response to their infants' distressed faces less negatively than healthy mothers. Blunted dlPFC response and aberrant fronto-limbic connectivity while viewing own infant faces and less negative ratings of own infants' distress in BD mothers may affect their responses to their own infants in real-life mother-infant interactions.
Competing Interests: Conflicts of interests Kamilla Miskowiak has received consultancy fees from Lundbeck and Janssen-Cilag in the past three years. Rene E Nielsen has received research grants from H. Lundbeck and Otsuka Pharmaceuticals for clinical trials, received speaking fees from Bristol-Myers Squibb, Astra Zeneca, Janssen & Cilag, Lundbeck, Servier, Otsuka Pharmaceuticals, Teva A/S, and Eli Lilly and has acted as advisor to Astra Zeneca, Eli Lilly, Lundbeck, Otsuka Pharmaceuticals, Takeda, and Medivir, and has acted as investigator for Janssen-Cilag, Lundbeck, Boehringer, Compass and Sage. Lars Vedel Kessing has within recent three years been a consultant for Lundbeck and Teva. Anne Bjertrup, Julian Macoveanu, Heidemarie Laurent, Mala Moszkowicz, Megan Kate Finnegan, Ida Egmose, Patrick MacDonald Fisher, Anne Katrine Pagsberg, and Mette Væver report no conflicts of interests.
(Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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