Keratoconus enlargement as a predictor of keratoconus progression.

Autor: Cunha AM; Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal. ana.cunha.18@gmail.com.; Department of Ophthalmology of São João Hospital, Avenida Prof. Hernâni Monteiro, 4202 - 451, Porto, Portugal. ana.cunha.18@gmail.com., Correia PJ; Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Alves H; Department of Biomedicine, Faculty of Medicine of University of Porto, Porto, Portugal., Torrão L; Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal., Moreira R; Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal., Falcão-Reis F; Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal.; Department of Surgery and Physiology, Faculty of Medicine of University of Porto, Porto, Portugal., Pinheiro-Costa J; Department of Ophthalmology, Centro Hospitalar Universitário São João, Porto, Portugal.; Department of Biomedicine, Faculty of Medicine of University of Porto, Porto, Portugal.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Oct 26; Vol. 11 (1), pp. 21079. Date of Electronic Publication: 2021 Oct 26.
DOI: 10.1038/s41598-021-00649-0
Abstrakt: Numerous approaches have been designated to document progression in keratoconus, nevertheless there is no consistent or clear definition of ectasia progression. In this present study, we aim to evaluate Keratoconus Enlargement (KCE) as a parameter to document ectasia progression. We define KCE as an increase of more than 1D in the anterior curvature of non-apical corneal areas. We have designed a longitudinal study in 113 keratoconic eyes to assess keratoconus progression. KCE was compared with variables commonly used for detection of keratoconus progression like Kmax, Km, K2, PachyMin, D-Index, Corneal Astigmatism and PRC of 3.0 mm centered on the thinnest point. The variations of keratometric readings, D-index and ELEBmax showed positive associations with KCE. Evaluating the performance of Kmax, D-index and KCE as isolated parameters to document keratoconus progression we found a sensitivity of 49%, 82% and 77% and a specificity of 100%, 95% and 66% to detect keratoconus progression (p < 0.001 for all). This difference in sensitivity can be explained by the changes in keratoconus outside the small area represented by Kmax. The inclusion of KCE should be considered in the evaluation of keratoconus progression in conjunction with other variables to increase the reliability of our clinical evaluation.
(© 2021. The Author(s).)
Databáze: MEDLINE
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