Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up.

Autor: Remmelzwaal S; Department of Epidemiology and Data Science, Amsterdam UMC, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands. S.Remmelzwaal@amsterdamumc.nl., Beulens JWJ; Department of Epidemiology and Data Science, Amsterdam UMC, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Elders PJM; Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Location VUmc, Amsterdam, The Netherlands., Stehouwer CDA; Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center+, Maastricht, The Netherlands., Handoko ML; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Appelman Y; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Empel V; Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands., Heymans SRB; Department of Cardiology, Maastricht University, CARIM School for Cardiovascular Diseases, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, bus 911, 3000, Leuven, Belgium., van Ballegooijen AJ; Department of Epidemiology and Data Science, Amsterdam UMC, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands.; Department of Nephrology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Oct 26; Vol. 11 (1), pp. 21046. Date of Electronic Publication: 2021 Oct 26.
DOI: 10.1038/s41598-021-00541-x
Abstrakt: We investigated the prospective associations of body composition with cardiac structure and function and explored effect modification by sex and whether inflammation was a mediator in these associations. Total body (BF), trunk (TF) and leg fat (LF), and total lean mass (LM) were measured at baseline by a whole body DXA scan. Inflammatory biomarkers and echocardiographic measures were determined both at baseline and follow-up in the Hoorn Study (n = 321). We performed linear regression analyses with body composition measures as determinant and left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) or left atrial volume index (LAVI) at follow-up as outcome. Additionally, we performed mediation analysis using inflammation at follow-up as mediator. The study population was 67.7 ± 5.2 years and 50% were female. After adjustment, BF, TF and LF, and LM were associated with LVMI with regression coefficients of 2.9 (0.8; 5.1)g/m 2.7 , 2.3 (0.6; 4.0)g/m 2.7 , 2.0 (0.04; 4.0)g/m 2.7 and - 2.9 (- 5.1; - 0.7)g/m 2.7 . Body composition measures were not associated with LVEF or LAVI. These associations were not modified by sex or mediated by inflammation. Body composition could play a role in the pathophysiology of LV hypertrophy. Future research should focus on sex differences in regional adiposity in relation with diastolic dysfunction.
(© 2021. The Author(s).)
Databáze: MEDLINE
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