Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects.
Autor: | Coşkun A; EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey.; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey., Carobene A; EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; and Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy., Aarsand AK; EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.; Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway., Aksungar FB; Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey.; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey., Serteser M; Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey.; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey., Sandberg S; EFLM Working Group on Biological Variation; EFLM TaskGroup for the Biological Variation Database; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.; Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital, Bergen, Norway.; Department of Global Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway., Díaz-Garzón J; EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of LaboratoryMedicine, La Paz University Hospital, Madrid, Spain.; Analytical Quality Commission, Spanish Society of Laboratory Medicine (SEQCML), Barcelona, Spain., Fernandez-Calle P; EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of LaboratoryMedicine, La Paz University Hospital, Madrid, Spain.; Analytical Quality Commission, Spanish Society of Laboratory Medicine (SEQCML), Barcelona, Spain., Karpuzoğlu FH; Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey.; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey., Coskun C; Department of Medical Biochemistry, Basaksehir Cam and Sakura City hospital, Basaksehir, Istanbul, Turkey., Kızılkaya E; School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey., Fidan D; School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey., Jonker N; EFLM Working Group on Biological Variation; EFLMTask Group for the Biological Variation Database; and Certe, Wilhelmina Ziekenhuis Assen, Assen, The Netherlands., Uğur E; School of Health Science, Acibadem Mehmet Ali Aydınlar University, Atasehir, Istanbul, Turkey., Unsal I; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey. |
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Jazyk: | angličtina |
Zdroj: | Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2021 Oct 22; Vol. 60 (4), pp. 533-542. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2022). |
DOI: | 10.1515/cclm-2021-0886 |
Abstrakt: | Objectives: Trace elements (TrEL) are nutritionally essential components in maintaining health and preventing diseases. There is a lack of reliable biological variation (BV) data for TrELs, required for the diagnosis and monitoring of TrEL disturbances. In this study, we aimed to provide updated within- and between-subject BV estimates for zinc (Zn), copper (Cu) and selenium (Se). Methods: Weekly serum samples were drawn from 68 healthy subjects (36 females and 32 males) for 10 weeks and stored at -80 °C prior to analysis. Serum Zn, Cu and Se levels were measured using inductively-coupled plasma mass spectrometry (ICP-MS). Outlier and variance homogeneity analyses were performed followed by CV-ANOVA (Røraas method) to determine BV and analytical variation estimates with 95% CI and the associated reference change values (RCV) for all subjects, males and females. Results: Significant differences in mean concentrations between males and females were observed, with absolute and relative (%) differences for Zn at 0.5 μmol/L (3.5%), Cu 2.0 μmol/L (14.1%) and Se 0.06 μmol/L (6.0%). The within-subject BV (CV Conclusions: The data of this study provides updated BV estimates for serum Zn, Cu and Se derived from a stringent protocol and state of the art methodologies. Furthermore, Cu and Se display marked individuality, highlighting that population based reference limits should not be used in the monitoring of patients. (© 2021 Walter de Gruyter GmbH, Berlin/Boston.) |
Databáze: | MEDLINE |
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