Liposomal SDF-1 Alpha Delivery in Nanocomposite Hydrogels Promotes Macrophage Phenotype Changes and Skin Tissue Regeneration.

Autor:	Yu JR; Fischell Department of Bioengineering, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.; NIH/NBIB Center for Engineering Complex Tissues, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.; University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Varrey P; Fischell Department of Bioengineering, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States., Liang BJ; Fischell Department of Bioengineering, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.; NIH/NCI, Laboratory of Cell Biology, Center for Cancer Research, Bethesda, Maryland 20892, United States., Huang HC; Fischell Department of Bioengineering, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Fisher JP; Fischell Department of Bioengineering, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.; NIH/NBIB Center for Engineering Complex Tissues, University of Maryland, College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, Maryland 20742, United States.
Jazyk:	angličtina
Zdroj:	ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2021 Nov 08; Vol. 7 (11), pp. 5230-5241. Date of Electronic Publication: 2021 Oct 26.
DOI:	10.1021/acsbiomaterials.1c01140
Abstrakt:	Skin regeneration in chronic wounds is often delayed due to persistent inflammation induced by underlying conditions such as diabetes. This effect is mediated, in part, by macrophages present in the wound, which can be stimulated to adopt either pro- or anti-inflammatory phenotypes depending on the status of the local microenvironment. In this work, the prohealing chemokine stromal cell-derived factor-1 alpha (SDF-1α) is controllably released from a hydrogel-based biomaterial to promote skin tissue regeneration and wound closure. This innovative nanocomposite hydrogel system releases liposomal stromal cell-derived factor-1 alpha (lipoSDF) as a new treatment approach for dorsal full-thickness skin wounds in wild-type and diabetic mice. Using this strategy, the recruitment and polarization of macrophages primarily of the anti-inflammatory phenotype were observed, along with a decreased amount of open wound surface area in diabetic mice after 28 days. This was accompanied by histological observations of increased epidermal stratification and dermal angiogenesis. These findings represent an important step of investigation distinctive in its field for developing immunomodulatory biomaterials that are able to influence macrophage phenotype and promote healing as hydrogel-based wound dressings.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu