| Autor: |
Coelho OGL; Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Alfenas RCG; Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Debelo H; Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA., Wightman JD; Welch Foods Inc., Concord, MA, USA., Ferruzzi MG; Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA., Mattes RD; Department of Nutrition Sciences, Purdue University, West Lafayette, IN, USA. mattes@purdue.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Food & function [Food Funct] 2021 Nov 15; Vol. 12 (22), pp. 11469-11481. Date of Electronic Publication: 2021 Nov 15. |
| DOI: |
10.1039/d1fo02049h |
| Abstrakt: |
Background & aims : Concord grape ( Vitis lambrusca ) juice (CGJ) contains a unique combination of polyphenolic compounds with diverse effects on human health. It also has an intense sensory profile that may modify food choice. Daily consumption of CGJ over 8 weeks reduced fasting blood glucose. However, the impact on 24h-postprandial glucose response from CGJ is still not clear. The purpose of this study was to assess the effect of CGJ flavor intensity and phenolic content on 24 h postprandial glucose concentrations, appetitive sensations, and cognitive function in adults with excess body weight when consumed alone or with a meal. Methods : In a randomized, double-blind, crossover design study, participants consumed three types of beverages: 100% CGJ, a polyphenol-free grape flavored drink with the same flavor essence (LP) or a polyphenol-free grape flavored drink with reduced flavor essence (LPF) either without (trial I) or with (trial II) a meal. 24 h glucose was measured through continuous glucose monitoring. Phenolic metabolite excretion was assessed in 24 h urine samples. Appetite (hunger, thirst, fullness, desire to eat, and prospective consumption) and cognitive function (alertness, energetic, strength, calmness, and relaxation) were assessed hourly through visual analog scales. Results : Thirty-four adults completed trial I and 34 adults completed trial II. When consumed with a meal, beverages with customary flavor essence (CGJ and LP) reduced hunger, desire to eat, and prospective consumption and consumption of the polyphenol-free reduced flavor essence beverage was associated with higher 24 h glucose t AUC. No consistent effects were observed for cognitive outcomes. When consumed alone, CGJ was related to lower glycemic responses by those excreting a higher concentration of the phenolic metabolite iso/ferulic-3'- O -glucuronide, but in beverages without CG phenolics and reduced flavor essence, glycemia was higher among those excreting higher concentrations of caffeic acid- O -sulfate. Conclusions : Both natural phenolics and flavor essence of CGJ may help to moderate appetite and glycemia. Clinical Trials registered at http://www.clinicaltrials.gov: NCT03409484 (trial I) and NCT03409497 (trial II). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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