Visual pursuit behavior in mice maintains the pursued prey on the retinal region with least optic flow.

Autor:	Holmgren CD; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Stahr P; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Wallace DJ; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Voit KM; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Matheson EJ; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Sawinski J; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany., Bassetto G; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany.; Machine Learning in Science, Eberhard Karls University of Tübingen, Tübingen, Germany., Kerr JN; Department of Behavior and Brain Organization, Research center caesar, Bonn, Germany.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Oct 26; Vol. 10. Date of Electronic Publication: 2021 Oct 26.
DOI:	10.7554/eLife.70838
Abstrakt:	Mice have a large visual field that is constantly stabilized by vestibular ocular reflex (VOR) driven eye rotations that counter head-rotations. While maintaining their extensive visual coverage is advantageous for predator detection, mice also track and capture prey using vision. However, in the freely moving animal quantifying object location in the field of view is challenging. Here, we developed a method to digitally reconstruct and quantify the visual scene of freely moving mice performing a visually based prey capture task. By isolating the visual sense and combining a mouse eye optic model with the head and eye rotations, the detailed reconstruction of the digital environment and retinal features were projected onto the corneal surface for comparison, and updated throughout the behavior. By quantifying the spatial location of objects in the visual scene and their motion throughout the behavior, we show that the prey image consistently falls within a small area of the VOR-stabilized visual field. This functional focus coincides with the region of minimal optic flow within the visual field and consequently area of minimal motion-induced image-blur, as during pursuit mice ran directly toward the prey. The functional focus lies in the upper-temporal part of the retina and coincides with the reported high density-region of Alpha-ON sustained retinal ganglion cells. Competing Interests: CH, PS, DW, KV, EM, JS, GB, JK No competing interests declared (© 2021, Holmgren et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu