| Autor: |
Aka KG; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.; MIVEGEC, University of Montpellier, IRD, CNRS, 34000 Montpellier, France., Yao SS; Unité de Paludologie, Institut Pasteur de Côte d'Ivoire, Abidjan 01 BP 490, Côte d'Ivoire., Gbessi EA; Unité de Paludologie, Institut Pasteur de Côte d'Ivoire, Abidjan 01 BP 490, Côte d'Ivoire., Adja AM; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.; UFR Biosciences, University Felix Houphouet Boigny, Abidjan 01 BP V34, Côte d'Ivoire., Corbel V; MIVEGEC, University of Montpellier, IRD, CNRS, 34000 Montpellier, France., Koffi AA; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire., Rogier C; Primum Vitare!, Paris, France.; Institut Pasteur de Madagascar, Antananarivo 101, Madagascar., Assi SB; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.; Programme National de Lutte contre le Paludisme, Abidjan, Côte d'Ivoire., Toure OA; Unité de Paludologie, Institut Pasteur de Côte d'Ivoire, Abidjan 01 BP 490, Côte d'Ivoire., Remoue F; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.; MIVEGEC, University of Montpellier, IRD, CNRS, 34000 Montpellier, France., Poinsignon A; Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.; MIVEGEC, University of Montpellier, IRD, CNRS, 34000 Montpellier, France. |
| Abstrakt: |
Humoral immunity to Plasmodium falciparum is acquired after repeated infections, and can lead to clinical protection. This study aimed to evaluate how human-, parasite-, and environment-related determinants can modulate the dynamics of IgG responses to Plasmodium falciparum after an infection. Individuals ( n = 68, average age = 8.2 years) with uncomplicated malaria were treated with ACT and followed up for 42 days. IgG responses to P. falciparum merozoite antigens ( Pf MSP1 , Pf MSP3 , Pf AMA1 , Pf GLURP-R0), to whole schizont extract ( Pf Schz), and to Anopheles gSG6-P1 and Aedes Nterm-34 kDa salivary peptides were measured. Regression analyses were used to identify factors that influence the dynamics of IgG response to P. falciparum antigen between D0 and D42, including demographic and biological factors and the level of exposure to mosquito bites. The dynamics of IgG response to P. falciparum differed according to the antigen. According to multivariate analysis, IgG responses to Pf Schz and to Pf GLURP-R0 appear to be affected by exposure to Aedes saliva and are associated with age, parasite density, and anti- Plasmodium pre-existing immune response at study inclusion. The present work shows that human exposure to Aedes saliva may contribute, in addition to other factors, to the regulation of anti- Plasmodium immune responses during a natural infection. |
