Immune checkpoint proteins (PD-L1 and CTLA-4) in endometrial carcinoma: prognostic role and correlation with CD4 + /CD8 + tumor infiltrating lymphocytes (TILs) ratio.

Autor: Khalifa R; Department of pathology, Faculty of Medicine, Pathology, Tanta University, Tanta, Egypt., Elsese N; Department of pathology, Faculty of Medicine, Pathology, Tanta University, Tanta, Egypt., El-Desouky K; Department of pathology, Faculty of Medicine, Pathology, Tanta University, Tanta, Egypt., Shaair H; Department of pathology, Faculty of Medicine, Pathology, Tanta University, Tanta, Egypt., Helal D; Department of pathology, Faculty of Medicine, Pathology, Tanta University, Tanta, Egypt.
Jazyk: angličtina
Zdroj: Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2022 Mar 04; Vol. 43 (2), pp. 192-212. Date of Electronic Publication: 2021 Oct 26.
DOI: 10.1080/15321819.2021.1981377
Abstrakt: Developing the prognostic aspects of endometrial carcinoma through shedding light on immune check point proteins (PD-L1 and CTLA-4) together with Tumor-Infiltrating Lymphocytes (TILs) may help finding new targets for immunotherapy, especially for advanced cases. This study aimed to study the immunohistochemical expression of PD-L1 and CTLA-4 in correlation with tumor infiltrating lymphocytes (TILs) in series of endometrial carcinomas. CTLA-4 showed notably higher frequency of expression in the studied cases than PD-L1. However, both showed significant association across different histopathological subtypes. PD-L1 immunohistochemical expression in studied endometrial carcinomas was significantly associated with low CD4 + /CD8 + ratio, high tumor grades, presence of lymph node metastasis and higher tumor stage. CTLA-4 immunohistochemical expression in studied endometrial carcinomas was significantly associated with low CD4 + /CD8 + ratio and high tumor grades but not with tumor stage. Both PD-L1 & CTLA-4 are expressed in subset of endometrial carcinomas with more prevalence of the latter. Both immune checkpoint proteins have significant correlation with different prognostic clinicopathological parameters together with TILs (CD4 & CD8 and their ratio). Increased activated cytotoxic T lymphocytes and PD-L1 expression in endometrial carcinomas may suggest identification of patients' subset of tumors that can be candidates for treatment with immunotherapy.
Databáze: MEDLINE
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