Mathematical modeling accurately predicts the dynamics and scaling of nuclear growth in discrete cytoplasmic volumes.

Autor: Leech V; Dept. of Mathematics, University College London, London WC1H 0AY, UK. Electronic address: vivienne.leech.16@ucl.ac.uk., Hazel JW; Dept. of Molecular Biology, U. Wyoming, Laramie, WY 82071, USA; Cell Division and Organization Group, Marine Biological laboratory, Woods Hole 02543, MA, USA., Gatlin JC; Dept. of Molecular Biology, U. Wyoming, Laramie, WY 82071, USA; Cell Division and Organization Group, Marine Biological laboratory, Woods Hole 02543, MA, USA. Electronic address: jgatlin@uwyo.edu., Lindsay AE; Dept. of Applied and Computational Mathematics and Statistics, University of Notre Dame, South Bend 46656, IN, USA. Electronic address: a.lindsay@nd.edu., Manhart A; Dept. of Mathematics, University College London, London WC1H 0AY, UK. Electronic address: a.manhart@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Journal of theoretical biology [J Theor Biol] 2022 Jan 21; Vol. 533, pp. 110936. Date of Electronic Publication: 2021 Oct 22.
DOI: 10.1016/j.jtbi.2021.110936
Abstrakt: Scaling of nuclear size with cell size has been observed in many species and cell types. In this work we formulate a modeling framework based on the limiting component hypothesis. We derive a family of spatio-temporal mathematical models for nuclear size determination based on different transport and growth mechanisms. We analyse model properties and use in vitro experimental data to identify the most probable mechanism. This suggests that nuclear volume scales with cell volume and that a nucleus controls its import rate as it grows. We further test the model by comparing to data of early frog development, where rapid cell divisions set the relevant time scales.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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