Reproductive responses of rice field rats (Rattus argentiventer) following treatment with the contraceptive hormones, quinestrol and levonorgestrol.

Autor: Stuart AM; International Rice Research Institute - Indonesia Office, Bogor, Indonesia.; Pesticide Action Network UK, Brighton, UK., Herawati N'; Indonesian Center for Rice Research, Sukamandi, Indonesia.; Indonesian Legume and Tuber Crops Research Institute, Malang, Indonesia., Risnelli; International Rice Research Institute - Indonesia Office, Bogor, Indonesia., Sudarmaji; Assessment Institute for Agricultural Technology, Yogyakarta, Indonesia., Liu M; International Society of Zoological Sciences, Beijing, China., Zhang Z; State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China., Li H; State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Singleton GR; International Rice Research Institute, Los Banos, Philippines.; Natural Resources Institute, University of Greenwich, Chatham Maritime, Kent, UK., Hinds LA; CSIRO Health and Biosecurity, Canberra, ACT, Australia.
Jazyk: angličtina
Zdroj: Integrative zoology [Integr Zool] 2022 Nov; Vol. 17 (6), pp. 1017-1027. Date of Electronic Publication: 2021 Nov 11.
DOI: 10.1111/1749-4877.12598
Abstrakt: The rice field rat, Rattus argentiventer, is a significant pest of rice in Southeast Asia. Fertility control methods have the potential to provide safe and effective alternatives to control methods that often include indiscriminate use of rodenticides or electric barriers. The aim of this laboratory study was to assess uptake of bait coated with different concentrations of the contraceptive hormones, quinestrol (E) and levonorgestrel (P), delivered alone and in combination (i.e. EP-1) and determine the short-term effects on reproductive parameters of adult male and female R. argentiventer. In Experiment 1, 2 concentrations of E, P, and EP-1 (10, 20 ppm) were fed to groups of wild-caught rats for 7 days. In females, both E and EP-1 induced uterine edema. In males, EP-1 reduced epididymis and seminal vesicle weights and lowered sperm motility. However, these responses were inconsistent due to low bait acceptance, especially with increasing concentrations. In Experiment 2, EP-1 (0, 20, 50, 100 ppm) was administered by oral gavage daily for 7 days to male R. argentiventer. There were significant reductions in epididymal and seminal vesicle weights for all oral doses of EP-1, in sperm counts for the 50 ppm dose, and in sperm motility for the 20 and 50 ppm doses compared to the control group. To select the optimum dose of EP-1, we must address the poor acceptance of contraceptive-coated baits by rice field rats. Further research is required to improve the palatability of EP-1 and to test its uptake under field conditions.
(© 2021 International Society of Zoological Sciences, Institute of Zoology/Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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