| Autor: |
Seumo AS; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Nanfack ARD; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Ndontsa BL; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Bitchagno GTM; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon.; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany., Mbouangouere R; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon., Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany., Tane P; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Tene M; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon., Ngouela SA; Faculty of Sciences, Department of Chemistry, University of Dschang, Cameroon. |
| Abstrakt: |
A phytochemical study of the methanol extract of the fruit of Maesa lanceolata resulted in the isolation of a new alkenylbenzoquinone ( 1 ), alongside the known compounds ( Z )-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone ( 2 ), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone ( 3 ), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone ( 4 ), (2 S ,3 S ,4 R ,2' R ,9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol ( 5 ), monopalmitin (glyceryl palmitate) ( 6 ), lupeol ( 7 ), and 3- O -( β -D-glucopyranoside)- β -sitosterol ( 8 ). The structures of the compounds were established by the means of spectroscopic (1 D- and 2 D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities. Compound 2 showed moderate activity against Staphylococcus warneri (DSMZ 20036), while the other compounds were inactive. The two quinones 1 and 2 were significantly cytotoxic, with IC 50 values of 0.005 µ M and 12.5 µ M respectively, and were weakly active towards DPPH radical (IC 50 >250 µ g/mL). |
