In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife.
| Autor: | Akinola LK; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.; Department of Chemistry, Bauchi State University, Gadau, Nigeria., Uzairu A; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria., Shallangwa GA; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria., Abechi SE; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | Current research in toxicology [Curr Res Toxicol] 2021 Sep 30; Vol. 2, pp. 357-365. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021). |
| DOI: | 10.1016/j.crtox.2021.09.003 |
| Abstrakt: | Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated. In this paper, the susceptibility of the endocrine system to disruption by PCDF congeners via nuclear receptor binding was studied using molecular docking simulation. Findings revealed that some PCDF congeners exhibit high probabilities of binding to androgen receptor in its agonistic and antagonistic conformations. In depth molecular docking analysis of the receptor-ligand complexes formed by PCDFs with androgen receptor in its agonistic and antagonistic conformations showed that, these complexes were stabilized by electrostatic, van der Waals, pi-effect and hydrophobic interactions. It was also observed that PCDF molecules mimic the modes of interaction observed in androgen-testosterone and androgen-bicalutamide complexes, utilizing between 65 and 83% of the amino acid residues used by the co-crystallized ligands for binding. This computational study suggests that some PCDF congeners may act as agonists and antagonists of androgen receptor in humans and wildlife via inapproprate binding to the receptor. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors.) |
| Databáze: | MEDLINE |
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